The HIF1α polymorphism rs2301104 is associated with obesity and obesity-related cytokines in Han Chinese population
The HIF1α polymorphism rs2301104 is associated with obesity and obesity-related cytokines in Han Chinese population
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HIF1α多态性rs2301104与中国汉族人群肥胖及肥胖相关细胞因子相关
DOI：
10.1007/s00592-022-02008-5
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发表时间：
2022-11
影响因子：
3.8
通讯作者：
Ren Wei
中科院分区：
文献类型：
--
作者：
Zheng Xiaoya;Ma Jiani;Long Jian;Wei Qiang;Ren Wei
目的探讨HIF 1 α基因多态性与中国汉族人群肥胖及肥胖相关细胞因子的关系。方法本研究包括160例肥胖受试者和166例年龄和性别匹配的健康对照。我们采用基于基质辅助激光解吸电离飞行时间质谱（MALDI-TOF MS）的基因分型技术对HIF 1 α的3个标签单核苷酸多态性（SNP）进行基因分型。在Luminex平台上测定血浆细胞因子浓度。的遗传协会进行了分析statistics.ResultsObese科目有显着的肥胖相关的代谢异常，包括高血脂症，胰岛素抵抗，血脂异常，肝酶，尿酸水平。HIF 1 α基因多态性分析显示，rs 2301104等位基因和基因型频率与肥胖显著相关。结果提示，rs 2301104的C等位基因可能是肥胖的保护性突变，CC/CG基因型可能是肥胖的保护性基因型。我们还发现，与CC/CG基因型的rs 2301104的受试者有显着较低的IL-6，TNF-α，IL-1β，IL-8和IL-10的水平比GG genotype.ConclusionsThis是第一个研究报告HIF 1 α多态性和肥胖和肥胖相关的细胞因子在中国汉族人群之间的关联。这些结果需要在更大的人群中重复，但表明HIF 1 α可能在肥胖发展中发挥重要作用。
AimsTo evaluate the association between genetic polymorphisms of HIF1α and obesity and obesity-related cytokines in the Han Chinese population.MethodsThe study consisted of 160 subjects with obesity and 166 age- and gender-matched healthy controls. We genotyped three tag single nucleotide polymorphisms (SNPs) of HIF1α by using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS)-based genotyping technology. Plasma cytokine concentrations were determined on the Luminex platform. The genetic associations were analysed statistically.ResultsObese subjects had significant obesity-related metabolic abnormalities, including hyperglycaemia, insulin resistance, and abnormalities in blood lipids, liver enzymes, and uric acid levels. SNP analysis of HIF1α revealed that the allele and genotype frequencies of rs2301104 were significantly associated with obesity. Our results suggest that the minor allele C of rs2301104 might be a protective mutation of obesity, and CC/CG genotypes of rs2301104 could be protective genotype of obesity. We also found that subjects with CC/CG genotypes of rs2301104 had significantly lower levels of IL-6, TNF-α, IL-1β, IL-8, and IL-10 than subjects with GG genotypes.ConclusionsThis is the first study to report an association between HIF1α polymorphisms and obesity and obesity-related cytokines in a Han Chinese population. These results require replication in larger populations but suggest that HIF1α may play an important role in obesity development.
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影响因子：
4.6
作者：
Dowal L;Parameswaran P;Phat S;Akella S;Majumdar ID;Ranjan J;Shah C;Mogre S;Guntur K;Thapa K;Gesta S;Vishnudas VK;Narain NR;Sarangarajan R
通讯作者：
Sarangarajan R
影响因子：
64.5
作者：
Lee YS;Kim JW;Osborne O;Oh DY;Sasik R;Schenk S;Chen A;Chung H;Murphy A;Watkins SM;Quehenberger O;Johnson RS;Olefsky JM
通讯作者：
Olefsky JM
影响因子：
12.3
作者：
Meeks KAC;Bentley AR;Gouveia MH;Chen G;Zhou J;Lei L;Adeyemo AA;Doumatey AP;Rotimi CN
通讯作者：
Rotimi CN
DOI：
10.3410/f.1097164.553169
发表时间：
2007-12
期刊：
--
影响因子：
--
作者：
P. Lepper
通讯作者：
P. Lepper
影响因子：
3.8
作者：
Juge-Aubry, CE;Somm, E;Meier, CA
通讯作者：
Meier, CA