Novel sorbents for removal of gadolinium-based contrast agents in sorbent dialysis and hemoperfusion: preventive approaches to nephrogenic systemic fibrosis.
Novel sorbents for removal of gadolinium-based contrast agents in sorbent dialysis and hemoperfusion: preventive approaches to nephrogenic systemic fibrosis.
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DOI：
10.1016/j.nano.2009.05.002
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发表时间：
2010-02
影响因子：
5.4
通讯作者：
Raymond, Kenneth N.
中科院分区：
文献类型：
--
作者：
Yantasee, Wassana;Fryxell, Glen E.;Porter, George A.;Pattamakomsan, Kanda;Sukwarotwat, Vichaya;Chouyyok, Wilaiwan;Koonsiripaiboon, View;Xu, Jide;Raymond, Kenneth N.
最近，许多形式的有机络合Gd造影剂与肾衰竭患者中的一种称为肾源性系统性纤维化（NSF）的衰弱和潜在致命的皮肤病有关。从这些配合物中释放的游离Gd被认为是NSF最重要的触发因素。在这项工作中，已经用1-羟基-2-吡啶酮（1，2-HOPO-SAMMS）功能化的纳米结构二氧化硅材料已经被评估用于从透析液和血液中选择性和有效地去除游离和螯合Gd（钆喷酸葡胺和钆双胺）。1，2-HOPO SAMMS对游离和螯合Gd具有高亲和力、快速去除率和大吸附容量;其性能远远优于目前在最先进的吸附剂透析和血液灌流系统中使用的活性炭和磷酸锆。基于SAMMS的吸附剂透析和血液灌流将可能提供一种有效且可预测的策略，用于清除接触Gd后肾功能受损患者的Gd，从而允许继续使用基于Gd的造影剂MRI，同时消除NSF的风险。
Many forms of organocomplexed Gd contrast agents have recently been linked to a debilitating and a potentially fatal skin disease called Nephrogenic Systemic Fibrosis (NSF) in patients with renal failure. Free Gd released from these complexes via transmetallation is believed to be the most important trigger for NSF. In this work, nanostructure silica materials that have been functionalized with 1-hydroxy-2-pyridinone (1,2-HOPO-SAMMS) have been evaluated for selective and effective removal of both free and chelated Gd (gadopentetate dimeglumine and gadodiamide) from dialysate and blood. 1,2-HOPO SAMMS has high affinity, rapid removal rate, and large sorption capacity for both free and chelated Gd; properties that are far superior to those of activated carbon and zirconium phosphate currently used in the state-of-the-art sorbent dialysis and hemoperfusion systems. The SAMMS-based sorbent dialysis and hemoperfusion will potentially provide an effective and predicable strategy for removing the Gd from patients with impaired renal function following Gd exposure, thus allowing for the continued use of Gd based contrast MRI, while removing the risk of NSF.
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影响因子：
--
作者：
Fryxell, GE;Wu, H;Kelly, S
通讯作者：
Kelly, S
影响因子：
6.1
作者：
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通讯作者：
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影响因子：
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作者：
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Valeri, Anthony M.
影响因子：
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作者：
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通讯作者：
Nagura, Yuji
影响因子：
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作者：
High, Whitney A.;Ayers, Reed A.;Cowper, Shawn E.
通讯作者：
Cowper, Shawn E.