Cell-Based Therapies Used to Treat Lumbar Degenerative Disc Disease: A Systematic Review of Animal Studies and Human Clinical Trials.
Cell-Based Therapies Used to Treat Lumbar Degenerative Disc Disease: A Systematic Review of Animal Studies and Human Clinical Trials.
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DOI：
10.1155/2015/946031
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发表时间：
2015
影响因子：
4.3
通讯作者：
Jenkin G
中科院分区：
文献类型：
--
作者：
Oehme D;Goldschlager T;Ghosh P;Rosenfeld JV;Jenkin G
腰痛和椎间盘退行性疾病是全球疼痛和残疾的重要原因。再生医学和基于细胞的疗法的进展，特别是间充质干细胞和椎间盘软骨细胞的移植，已经导致许多研究和临床试验的出版，利用这些生物疗法来治疗退行性脊柱疾病，通常报告有利的结果。干细胞介导的椎间盘再生可能会弥合目前腰痛患者的两种替代方案之间的差距，通常一端疼痛管理不足，另一端是侵入性手术。通过软骨形成和椎间盘再生或通过疼痛通路的修饰，干细胞非常适合于增强脊柱手术实践。本文将系统地综述利用细胞疗法修复退变椎间盘的基础研究、临床前和临床试验的现状。将讨论移植细胞的作用机制以及已发表研究的局限性。
Low back pain and degenerative disc disease are a significant cause of pain and disability worldwide. Advances in regenerative medicine and cell-based therapies, particularly the transplantation of mesenchymal stem cells and intervertebral disc chondrocytes, have led to the publication of numerous studies and clinical trials utilising these biological therapies to treat degenerative spinal conditions, often reporting favourable outcomes. Stem cell mediated disc regeneration may bridge the gap between the two current alternatives for patients with low back pain, often inadequate pain management at one end and invasive surgery at the other. Through cartilage formation and disc regeneration or via modification of pain pathways stem cells are well suited to enhance spinal surgery practice. This paper will systematically review the current status of basic science studies, preclinical and clinical trials utilising cell-based therapies to repair the degenerate intervertebral disc. The mechanism of action of transplanted cells, as well as the limitations of published studies, will be discussed.
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影响因子：
4
作者：
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通讯作者：
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影响因子：
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影响因子：
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