The hypothalamic RFamide, QRFP, increases feeding and locomotor activity: The role of Gpr103 and orexin receptors.
The hypothalamic RFamide, QRFP, increases feeding and locomotor activity: The role of Gpr103 and orexin receptors.
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DOI：
10.1371/journal.pone.0275604
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发表时间：
2022
期刊：
影响因子：
3.7
通讯作者：
Luckman, Simon M.
中科院分区：
文献类型：
--
作者：
Cook, Chris;Nunn, Nicolas;Worth, Amy A.;Bechtold, David A.;Suter, Todd;Gackeheimer, Susan;Foltz, Lisa;Emmerson, Paul J.;Statnick, Michael A.;Luckman, Simon M.
在这里，我们表明，中央管理焦谷氨酰甘氨酸-苯胺-酰胺肽（QRFP/26 RFa）增加食物摄入和运动活动，没有任何显着的影响，能量消耗，产热或奖励。小鼠QRFP受体直系同源物Gpr 103 a和Gpr 103 b的种系敲除均不产生代谢表型。然而，这两种受体都是中枢给药QRFP增加摄食和运动活性所需的。由于中枢注射QRFP激活了下丘脑外侧的食欲素/下丘脑泌素神经元，我们比较了QRFP和食欲素对行为的作用。这两种肽增加唤醒和运动活动。然而，虽然食欲素增加了消费行为，但QRFP也影响了其他食欲行为。此外，通过共同施用食欲素受体1拮抗剂来阻断对QRFP的进食而非运动反应。这些结果表明，QRFP激动诱导食欲和消费行为，但只有后者是依赖于食欲素/下丘脑泌素受体信号。
Here we show that central administration of pyroglutamylated arginine-phenylamine-amide peptide (QRFP/26RFa) increases both food intake and locomotor activity, without any significant effect on energy expenditure, thermogenesis or reward. Germline knock out of either of the mouse QRFP receptor orthologs, Gpr103a and Gpr103b, did not produce a metabolic phenotype. However, both receptors are required for the effect of centrally administered QRFP to increase feeding and locomotor activity. As central injection of QRFP activated orexin/hypocretin neurons in the lateral hypothalamus, we compared the action of QRFP and orexin on behaviour. Both peptides increased arousal and locomotor activity. However, while orexin increased consummatory behaviour, QRFP also affected other appetitive behaviours. Furthermore, the feeding but not the locomotor response to QRFP, was blocked by co-administration of an orexin receptor 1 antagonist. These results suggest that QRFP agonism induces both appetitive and consummatory behaviour, but only the latter is dependent on orexin/hypocretin receptor signalling.
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