Matrix remodeling in chronic lung diseases.
Matrix remodeling in chronic lung diseases.
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DOI：
10.1016/j.matbio.2018.03.012
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发表时间：
2018-11
期刊：
影响因子：
--
通讯作者：
Kheradmand F
中科院分区：
文献类型：
--
作者：
Gu BH;Madison MC;Corry D;Kheradmand F
多细胞生物合成和更新其亚细胞和支架蛋白的成分，统称为细胞外基质分子（ecm）。在肺中，ecm维持拉伸强度和弹性，并决定多种细胞系的特殊功能。这些功能在肺内平衡过程中至关重要，包括细胞在形态发生或修复过程中的迁移和增殖。由于内源性蛋白酶或外源性毒素的作用，肺ecm发生改变，使细胞暴露于新的隐性片段，这与几种常见呼吸道疾病的发生有关。肺ecm如何向上皮细胞和间充质细胞提供或传递重要信号，为几种常见慢性呼吸系统疾病的发生和进展提供了新的线索。这篇综述将探讨ecm如何调节肺稳态及其在病理条件下的重组，从而调节炎症性疾病哮喘、慢性阻塞性肺疾病（COPD）和特发性肺纤维化（IPF）。更好地了解肺ECM分布的变化可以为慢性肺部疾病的治疗提供新的治疗方法。
Multicellular organisms synthesize and renew components of their subcellular and scaffolding proteins, collectively known as the extracellular matrix molecules (ECMs). In the lung, ECMs maintain tensile strength, elasticity, and dictate the specialized function of multiple cell lineages. These functions are critical in lung homeostatic processes including cellular migration and proliferation during morphogenesis or in response to repair. Alterations in lung ECMs that expose cells to new cryptic fragments, generated in response to endogenous proteinases or exogenous toxins, are associated with the development of several common respiratory diseases. How lung ECMs provide or relay vital signals to epithelial and mesenchymal cells has shed new light on development and progression of several common chronic respiratory diseases. This review will consider how ECMs regulate lung homeostasis and their reorganization under pathological conditions that can modulate the inflammatory diseases asthma, chronic obstructive pulmonary disease (COPD), and idiopathic pulmonary fibrosis (IPF). Better understanding of changes in the distribution of lung ECM could provide novel therapeutic approaches to treat chronic lung diseases.
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影响因子：
3.8
作者：
Balestrini, Jenna L.;Niklason, Laura E.
通讯作者：
Niklason, Laura E.
DOI：
10.3109/08977194.2011.595714
发表时间：
2011-10
期刊：
Growth factors (Chur, Switzerland)
影响因子：
--
作者：
Biernacka A;Dobaczewski M;Frangogiannis NG
通讯作者：
Frangogiannis NG
影响因子：
30.5
作者：
Corry, DB;Rishi, K;Kheradmand, F
通讯作者：
Kheradmand, F
DOI：
10.1152/ajplung.00530.2005
发表时间：
2006-08-01
影响因子：
4.9
作者：
DiCamillo, Sandra J.;Yang, Shenghong;Panchenko, Mikhail P.
通讯作者：
Panchenko, Mikhail P.
DOI：
10.1165/ajrcmb/3.5.507
发表时间：
1990-11-01
影响因子：
6.4
作者：
BREWSTER, CEP;HOWARTH, PH;ROCHE, WR
通讯作者：
ROCHE, WR