Regulating Il9 transcription in T helper cells.

Regulating Il9 transcription in T helper cells.
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DOI:
10.1016/j.it.2011.01.006
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发表时间:
2011-04
影响因子:
16.8
通讯作者:
Kaplan MH
Kaplan MH
中科院分区:
医学1区
文献类型:
--
作者:
Perumal NB;Kaplan MH

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辅助性T细胞对感染和炎症性疾病的免疫发展至关重要。获得特定的细胞因子分泌谱,由细胞因子微环境引发,是Th细胞的效应功能所必需的。最近加入到不断增长的效应亚群列表的是分泌IL-9的Th9细胞。在本文中,我们提出了il -9基因在表达il -9的T细胞中的转录调控模型,以及该亚群与其他Th表型的关系。我们认为局限于某些Th亚群的转录因子可能在Th9细胞的可塑性中起作用,并且在几个亚群中很常见。
T helper cells are critical for the development of immunity to infections and inflammatory disease. The acquisition of specific cytokine-secreting profiles, primed by the cytokine microenvironment, is required for effector function of Th cells. The most recent addition to the growing list of effector subsets are Th9 cells that secrete IL-9. In this article we propose a model for the transcriptional regulation of the Il9 gene in IL-9-expressing T cells and the relatedness of this subset to other Th phenotypes. We suggest that transcription factors restricted to certain Th subsets, and common among several subsets, may play a role in the plasticity of Th9 cells.
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