A brief history of IL-9.

A brief history of IL-9.
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DOI:
10.4049/jimmunol.1003049
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发表时间:
2011-03-15
期刊:
Journal of immunology (Baltimore, Md. : 1950)
影响因子:
--
通讯作者:
Kaplan MH
Kaplan MH
中科院分区:
其他
文献类型:
--
作者:
Goswami R;Kaplan MH

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白介素9在20世纪80年代末首次被描述为在免疫系统中具有多效性功能的越来越多的细胞因子中的一员。尽管许多生物学功能都归因于IL-9,但它仍然是一个研究较少的细胞因子。最近的工作证明了IL-9在调节炎症免疫中的作用,并确定了在最有效地产生IL-9的细胞中激活IL9基因的转录因子,从而刺激了人们对IL-9的兴趣的复苏。在这篇综述中,我们总结了IL-9生物学活性的特征,强调了明确定义的细胞因子的作用,并概述了关于IL-9功能的问题,仍需进一步研究。
Interleukin-9 was first described in the late 1980s as a member of a growing number of cytokines that had pleiotropic functions in the immune system. Although many biological functions have been attributed to IL-9, it remains an understudied cytokine. A resurgence of interest in IL-9 has been spurred by recent work demonstrating a role for IL-9 in regulating inflammatory immunity, and in defining the transcription factors that activate the Il9 gene in cells that most efficiently produce IL-9. In this review we summarize the characterization of IL-9 biological activities, highlight roles for the cytokine that are clearly defined, and outline questions regarding IL-9 functions that still require further exploration.
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