Sex related differences in the pathogenesis of organ fibrosis.
Sex related differences in the pathogenesis of organ fibrosis.
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DOI：
10.1016/j.trsl.2020.03.008
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发表时间：
2020-08
期刊：
影响因子：
--
通讯作者：
Villarreal F
中科院分区：
文献类型：
--
作者：
Garate-Carrillo A;Gonzalez J;Ceballos G;Ramirez-Sanchez I;Villarreal F
器官纤维化的发展已经引起越来越多的关注，因为越来越多和/或高患病率的多种疾病似乎进展到慢性阶段。心脏、肾脏、肝脏和肺的情况就是如此，其中疾病如糖尿病、特发性/自身免疫性疾病和非酒精性肝病似乎显著地驱动纤维化的发展。值得注意的是，这些病理学的严重程度特征性地因衰老而加重。由于这些原因，研究小组和制药公司已经将纤维化确定为目前基本上没有有效选择的治疗靶点。虽然发表的研究有限，但大多数文献表明，在多个器官中，绝经前妇女不会发生严重的纤维化，这表明性激素在减轻这一过程中发挥着重要作用。研究人员已经实施了与纤维化相关的器官疾病的相关动物模型，这些观察结果总体上得到了支持。体外研究和转基因动物模型也被用于试图了解性激素和相关受体在纤维化发展中的作用。然而，在某些器官（如心脏）的慢性疾病中，老年（绝经后）妇女在几年内可以迅速接近疾病严重程度的男性，并发展出显著程度的纤维化。本文综述了目前的相关文献，并强调迫切需要一个主要的重点放在了解的方式，其中性别和相关激素的存在或不存在调节细胞表型，以允许纤维化的发展。
The development of organ fibrosis has garnered rising attention as multiple diseases of increasing and/or high prevalence appear to progress to the chronic stage. Such is the case for heart, kidney, liver, and lung where diseases such as diabetes, idiopathic/autoimmune disorders, and nonalcoholic liver disease appear to notably drive the development of fibrosis. Noteworthy is that the severity of these pathologies is characteristically compounded by aging. For these reasons, research groups and drug companies have identified fibrosis as a therapeutic target for which currently, there are essentially no effective options. Although a limited body of published studies are available, most literature indicates that in multiple organs, premenopausal women are protected from developing severe forms of fibrosis suggesting an important role for sex hormones in mitigating this process. Investigators have implemented relevant animal models of organ disease linked to fibrosis supporting in general, these observations. In vitro studies and transgenic animals models have also been used in an attempt to understand the role that sex hormones and related receptors play in the development of fibrosis. However, in the setting of chronic disease in some organs such as the heart older (postmenopausal) women within a few years can quickly approach men in disease severity and develop significant degrees of fibrosis. This review summarizes the current body of relevant literature and highlights the imperative need for a major focus to be placed on understanding the manner in which sex and the presence or absence of related hormones modulates cell phenotypes so as to allow for fibrosis to develop.
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影响因子：
20.1
作者：
Garcia M;Mulvagh SL;Merz CN;Buring JE;Manson JE
通讯作者：
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影响因子：
3.4
作者：
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影响因子：
5.5
作者：
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Villarreal, Francisco
DOI：
10.1016/s0735-1097(98)00347-7
发表时间：
1998-10-01
影响因子：
24
作者：
Douglas, PS;Katz, SE;Lorell, BH
通讯作者：
Lorell, BH
影响因子：
15.9
作者：
Berul, CI;Christe, ME;Mendelsohn, ME
通讯作者：
Mendelsohn, ME