Tumor necrosis factor-α inhibition improves endothelial function and decreases arterial stiffness in estrogen-deficient postmenopausal women.
Tumor necrosis factor-α inhibition improves endothelial function and decreases arterial stiffness in estrogen-deficient postmenopausal women.
复制标题
肿瘤坏死因子-α抑制可改善内皮功能，并降低绝经后雌性雌激素缺乏的动脉僵硬。
DOI：
10.1016/j.atherosclerosis.2013.07.057
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发表时间：
2013-10
期刊：
影响因子：
5.3
通讯作者：
Kohrt WM
中科院分区：
文献类型：
--
作者：
Moreau KL;Deane KD;Meditz AL;Kohrt WM
Tumor necrosis factor (TNF)-α, a pleiotropic pro-inflammatory cytokine involved in a variety of biological processes including oxidative stress, has been associated with vascular dysfunction in aged and ovariectomized animals. We determined whether acute inhibition of TNF-α improves vascular endothelial function and decreases arterial stiffness in estrogen-deficient postmenopausal women. Arterial stiffness (carotid artery compliance) and endothelial function (brachial artery flow-mediated dilation [FMD]) were measured in postmenopausal women (n=23; 57±1 years, mean±SE) before and following randomization to two days of either transdermal estradiol (0.05 mg/d, N=12) or placebo (N=11) alone and following a single subcutaneous injection of the TNF-α inhibitor, etanercept (25 mg), and in premenopausal (n=9; 33±2 years) before and following etanercept. Baseline carotid artery compliance and brachial artery FMD were lower in postmenopausal than premenopausal women (p<0.0001). In postmenopausal women, carotid artery compliance (n=12; 0.59±0.05 to 0.78±0.06 mm2/mmHg × 10−1, P<0.001) and FMD (4.1±0.6 to 6.0±0.7%, P=0.02) increased in response to estradiol but not placebo (n=11). Carotid artery compliance (0.71±0.06 to 0.81±0.06 mm2/mmHg × 10−1, P=0.02) and FMD (5.2±0.7 to 7.5±0.9%, P=0.003) increased with etanercept in the placebo group but had no effect in postmenopausal randomized to estradiol or premenopausal women. These results suggest that TNF-α contributes to impaired endothelial-dependent vasodilation and arterial stiffening in estrogen-deficient postmenopausal women.
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影响因子：
5.8
作者：
Moreau, Kerrie L.;Hildreth, Kerry L.;Kohrt, Wendy M.
通讯作者：
Kohrt, Wendy M.
DOI：
10.1152/ajpheart.00057.2005
发表时间：
2005-10-01
影响因子：
4.8
作者：
Mittermayer, F;Pleiner, J;Wolzt, M
通讯作者：
Wolzt, M
影响因子：
8.3
作者：
Moreau, KL;Gavin, KM;Seals, DR
通讯作者：
Seals, DR
影响因子：
5.8
作者：
Majmudar, NG;Robson, SC;Ford, GA
通讯作者：
Ford, GA
影响因子：
6
作者：
Csiszar, Anna;Labinskyy, Nazar;Ungvari, Zoltan
通讯作者：
Ungvari, Zoltan