Upregulation of Translationally Controlled Tumor Protein Is Associated With Cervical Cancer Progression.
Upregulation of Translationally Controlled Tumor Protein Is Associated With Cervical Cancer Progression.
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DOI：
10.3389/fmolb.2021.686718
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发表时间：
2021
影响因子：
5
通讯作者：
Tan Y
中科院分区：
文献类型：
--
作者：
Zhu X;Ren J;Xu D;Cheng D;Wang W;Ren J;Xiao Z;Jiang H;Ding Y;Tan Y
在一些疫苗接种和筛查覆盖率充足的富裕国家之外，宫颈癌仍然是许多国家妇女癌症相关死亡的主要原因。目前，一个主要问题是，相当大比例的患者在诊断时已经处于晚期癌症阶段。越来越多的证据表明，翻译控制肿瘤蛋白1 （TPT1）的过表达参与了癌症的发展，但对其在宫颈癌中的意义知之甚少。我们评估了ttpt1在宫颈炎、宫颈上皮内瘤变III型和宫颈癌患者的手术组织和血清以及正常和癌变宫颈细胞系中的水平。使用宫颈癌TCGA数据队列确定与TPT1相关的基因集、途径和功能蛋白相互作用。我们发现，与所有非恶性宫颈组织（包括宫颈炎、宫颈上皮内瘤III型和正常对照）相比，TPT1在宫颈癌组织中的表达显著增加。宫颈癌患者血清TPT1水平也高于健康人群。此外，TPT1表达升高与淋巴结转移和肿瘤低分化程度显著相关。在癌组织和细胞系中，检测到PI3K/AKT/mTOR通路过激活、凋亡抑制和EMT的选择性标记，并通过生物特征分析支持它们与TPT1的相互作用。我们的研究结果首次证明了TPT1表达上调与宫颈癌进展之间存在很强的相关性，提示TPT1可能为宫颈癌进展提供潜在的生物标志物。
Outside a few affluent countries with adequate vaccination and screening coverage, cervical cancer remains the leading cause of cancer-related deaths in women in many countries. Currently, a major problem is that a substantial proportion of patients are already at an advanced cancer stage when diagnosed. There is increasing evidence that indicates the involvement of translationally controlled tumor protein 1 (TPT1) overexpression in cancer development, but little is known about its implication in cervical cancer. We assessed the levels of TPT1 in surgical tissue and sera of patients with cervicitis, cervical intraepithelial neoplasia III, and cervical cancer, as well as in normal and cancerous cervical cell lines. Gene sets, pathways, and functional protein interactions associated with TPT1 were identified using the TCGA data cohort of cervical cancer. We found that the TPT1 expression was significantly increased in cervical cancer tissue compared to all nonmalignant cervical tissues, including samples of cervicitis, cervical intraepithelial neoplasia III, and normal controls. Serum level of TPT1 was also increased in cervical cancer patients compared to healthy subjects. Furthermore, elevated TPT1 expression was significantly correlated with lymph node metastasis and a low differentiation degree of the cancer. In the cancerous tissues and cell lines, selective markers of PI3K/AKT/mTOR pathway over-activation, apoptosis repression, and EMT were detected, and their interaction with TPT1 was supported by biometrics analyses. Our results, for the first time, demonstrate a strong correlation of upregulated TPT1 expression with cervical cancer progression, suggesting that TPT1 might provide a potential biomarker for cervical cancer progression.
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DOI：
10.1186/s12964-017-0164-3
发表时间：
2017-02-01
期刊：
Cell communication and signaling : CCS
影响因子：
--
作者：
Bommer UA;Vine KL;Puri P;Engel M;Belfiore L;Fildes K;Batterham M;Lochhead A;Aghmesheh M
通讯作者：
Aghmesheh M
影响因子：
3
作者：
Koziol MJ;Gurdon JB
通讯作者：
Gurdon JB
影响因子：
13.5
作者：
Chan, Tim Hon Man;Chen, Leilei;Guan, Xin-Yuan
通讯作者：
Guan, Xin-Yuan
通过亲和蛋白质组学鉴定翻译控制的肿瘤蛋白促进癌细胞 DNA 同源重组修复
影响因子：
8
作者：
Li Y;Sun H;Zhang C;Liu J;Zhang H;Fan F;Everley RA;Ning X;Sun Y;Hu J;Liu J;Zhang J;Ye W;Qiu X;Dai S;Liu B;Xu H;Fu S;Gygi SP;Zhou C
通讯作者：
Zhou C
影响因子：
4.8
作者：
Bommer, Ulrich-Axel;Iadevaia, Valentina;Proud, Christopher G.
通讯作者：
Proud, Christopher G.