Nucleocytoplasmic functions of the PDZ-LIM protein family: new insights into organ development.
Nucleocytoplasmic functions of the PDZ-LIM protein family: new insights into organ development.
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DOI：
10.1002/bies.200900148
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发表时间：
2010-02
期刊：
影响因子：
4
通讯作者：
Simon, Hans-Georg
中科院分区：
文献类型：
--
作者：
Krcmery, Jennifer;Camarata, Troy;Kulisz, Andre;Simon, Hans-Georg
最近对PDZ-LIM蛋白家族的研究揭示了其在细胞水平上的重要活性，介导细胞核和细胞骨架之间的信号，对器官发育有重要影响。我们回顾并整合了PDZ-LIM蛋白家族的现有知识，并提出了一种新的功能作用，即在细胞质中隔离核因子。PDZ-LIM家族以其PDZ和LIM结构域为特征，由从蠕虫到人类等动物王国中发现的进化保守蛋白组成。PDZ-LIM蛋白在一个蛋白中结合了两个功能域，在细胞发育和稳态过程中具有广泛和多室室的功能，而相反，失调可导致癌症的形成和进展。新出现的作用包括与整合素，T-box转录因子和受体酪氨酸激酶的相互作用。PDZ-LIM蛋白促进蛋白质复合物的组装，可以作为信号调节剂，影响肌动蛋白动力学，调节细胞结构和控制基因转录。
Recent work on the PDZ-LIM protein family has revealed important activities at the cellular level, mediating signals between the nucleus and the cytoskeleton, with significant impact on organ development. We review and integrate current knowledge about the PDZ-LIM protein family and propose a new functional role, sequestering nuclear factors in the cytoplasm. Characterized by their PDZ and LIM domains, the PDZ-LIM family is comprised of evolutionarily conserved proteins found throughout the animal kingdom, from worms to humans. Combining two functional domains in one protein, PDZ-LIM proteins have wide-ranging and multi-compartmental cell functions during development and homeostasis while, in contrast, misregulation can lead to cancer formation and progression. New emerging roles include interactions with integrins, T-box transcription factors, and receptor tyrosine kinases. Facilitating the assembly of protein complexes, PDZ-LIM proteins can act as signal modulators, influence actin dynamics, regulate cell architecture and control gene transcription.
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