Skeletal muscle myofibrillar protein metabolism in heart failure: relationship to immune activation and functional capacity.
Skeletal muscle myofibrillar protein metabolism in heart failure: relationship to immune activation and functional capacity.
复制标题
心力衰竭中的骨骼肌肌原纤维蛋白代谢：与免疫激活和功能能力的关系。
DOI：
10.1152/ajpendo.00444.2004
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
LeWinter,MartinM
中科院分区：
文献类型：
--
作者：
Toth,MichaelJ;Matthews,DwightE;Ades,PhilpA;Tischler,MarcD;VanBuren,Peter;Previs,Michael;LeWinter,MartinM
Chronic heart failure is characterized by changes in skeletal muscle that contribute to physical disability. Most studies to date have investigated defects in skeletal muscle oxidative capacity. In contrast, less is known about how heart failure affects myofibrillar protein metabolism. Thus we examined the effect of heart failure on skeletal muscle myofibrillar protein metabolism, with a specific emphasis on changes in myosin heavy chain (MHC) protein content, synthesis, and isoform distribution in 10 patients with heart failure (63 ± 3 yr) and 11 controls (70 ± 3 yr). In addition, we examined the relationship of MHC protein metabolism to inflammatory markers and physical function. Although MHC and actin protein content did not differ between groups, MHC protein content decreased with increasing disease severity in heart failure patients (r= −0.748,P< 0.02), whereas actin protein content was not related to disease severity. No difference in MHC protein synthesis was found between groups, and MHC protein synthesis rates were not related to disease severity. There were, however, relationships between C-reactive protein and both MHC protein synthesis (r= −0.442,P= 0.05) and the ratio of MHC to mixed muscle protein synthesis (r= −0.493,P< 0.03). Heart failure patients showed reduced relative amounts of MHC I (P< 0.05) and a trend toward increased MHC IIx (P= 0.06). In regression analyses, decreased MHC protein content was related to decreased exercise capacity and muscle strength in heart failure patients. Our results demonstrate that heart failure affects both the quantity and isoform distribution of skeletal muscle MHC protein. The fact that MHC protein content was related to both exercise capacity and muscle strength further suggests that quantitative alterations in MHC protein may have functional significance.
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DOI：
--
发表时间：
1998
期刊：
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
影响因子：
--
作者：
Y. Li;R. Schwartz;I. Waddell;B. Holloway;M. Reid
通讯作者：
Y. Li;R. Schwartz;I. Waddell;B. Holloway;M. Reid
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DOI：
10.1006/jmcc.1996.0158
发表时间：
1996
期刊：
Journal of molecular and cellular cardiology.
影响因子：
--
作者：
Simonini,A;Massie,BM;Long,CS;Qi,M;Samarel,AM
通讯作者：
Samarel,AM
影响因子：
3.3
作者：
Haddad, F;Roy, RR;Baldwin, KM
通讯作者：
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影响因子：
9.3
作者：
E. Macy;T. Hayes;R. Tracy
通讯作者：
E. Macy;T. Hayes;R. Tracy
DOI：
10.1111/j.1748-1716.1990.tb08974.x
发表时间：
1990-09-01
期刊：
ACTA PHYSIOLOGICA SCANDINAVICA
影响因子：
--
作者：
KLITGAARD, H;MANTONI, M;SALTIN, B
通讯作者：
SALTIN, B