Lifetime risk and age at diagnosis of symptomatic knee osteoarthritis in the US.
Lifetime risk and age at diagnosis of symptomatic knee osteoarthritis in the US.
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DOI：
10.1002/acr.21898
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发表时间：
2013-05
影响因子：
4.7
通讯作者：
Katz, Jeffrey N.
中科院分区：
文献类型：
--
作者：
Losina, Elena;Weinstein, Alexander M.;Reichmann, William M.;Burbine, Sara A.;Solomon, Daniel H.;Daigle, Meghan E.;Rome, Benjamin N.;Chen, Stephanie P.;Hunter, David J.;Suter, Lisa G.;Jordan, Joanne M.;Katz, Jeffrey N.
基于美国人群的自我报告，估计诊断为症状性膝关节OA的发病率和终生风险以及诊断为膝关节OA的年龄。我们通过结合2007-2008年国家健康访谈调查（NHIS）的年龄、性别和肥胖特异性患病率数据，以及骨关节炎政策（OAPol）模型（一种经验证的膝关节OA计算机模拟模型）得出的疾病持续时间估计值，估计了美国诊断的症状性膝关节OA的发病率。我们使用OAPol模型来估计诊断的平均年龄和中位年龄以及终身风险。55 - 64岁成人中诊断的症状性膝关节OA的估计发生率最高，范围为非肥胖男性每年0.37%至肥胖女性每年1.02%。膝关节OA诊断的估计中位年龄为55岁。估计的终生风险为13.83%，范围从非肥胖男性的9.60%到肥胖女性的23.87%。约9.29%的美国人群在60岁时被诊断为症状性膝关节OA。症状性膝关节OA的诊断发生在生命的相对早期，这表明预防计划应在生命过程的相对早期提供。需要进一步研究以了解膝关节OA早期诊断所导致的未来医疗保健利用负担。
To estimate incidence and lifetime risk of diagnosed symptomatic knee OA and age of diagnosis of knee OA based on self-reports in the US population. We estimated incidence of diagnosed symptomatic knee OA in the US by combining data on age-, sex-, and obesity-specific prevalence from the 2007–2008 National Health Interview Survey (NHIS) with disease duration estimates derived from the Osteoarthritis Policy (OAPol) Model, a validated computer simulation model of knee OA. We used the OAPol Model to estimate the mean and median ages of diagnosis and lifetime risk. The estimated incidence of diagnosed symptomatic knee OA was highest among adults aged 55 to 64, ranging from 0.37% per year for non-obese males to 1.02% per year for obese females. The estimated median age of knee OA diagnosis was 55 years. The estimated lifetime risk was 13.83%, ranging from 9.60% for non-obese males to 23.87% in obese females. About 9.29% of the US population is diagnosed with symptomatic knee OA by age 60. The diagnosis of symptomatic knee OA occurs relatively early in life suggesting that prevention programs should be offered relatively early in the life course. Further research is needed to understand the future burden of healthcare utilization resulting from earlier diagnosis of knee OA.
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作者：
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通讯作者：
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通讯作者：
Katz, JN
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通讯作者：
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