Cutting Edge: BAFF Overexpression Reduces Atherosclerosis via TACI-Dependent B Cell Activation.
Cutting Edge: BAFF Overexpression Reduces Atherosclerosis via TACI-Dependent B Cell Activation.
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DOI：
10.4049/jimmunol.1601198
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发表时间：
2016-12-15
期刊：
影响因子：
--
通讯作者：
Rawlings DJ
中科院分区：
文献类型：
--
作者：
Jackson SW;Scharping NE;Jacobs HM;Wang S;Chait A;Rawlings DJ
Patients with SLE exhibit accelerated atherosclerosis, a chronic inflammatory disease of the arterial wall. The impact of B cells in atherosclerosis is controversial, with both protective and pathogenic roles described. For example, natural IgM binding conserved oxidized lipid epitopes protect against atherosclerosis, while anti-oxidized low-density lipoprotein (oxLDL) IgG likely promotes disease. Since B cell activating factor of the TNF family (BAFF) promotes B cell class-switch recombination and humoral autoimmunity, we hypothesized that excess BAFF would accelerate atherosclerosis. In contrast, BAFF overexpression markedly reduced hypercholesterolemia and atherosclerosis in hyperlipidemic mice. BAFF-mediated atheroprotection required B cells and was associated with increased protective anti-oxLDL IgM. Surprisingly, high-titer anti-oxLDL IgM production and reduced atherosclerosis was dependent on the BAFF family receptor transmembrane activator and CAML interactor (TACI). In summary, we identified a novel role for B cell-specific, BAFF-dependent TACI signals in atherosclerosis pathogenesis, of particular relevance to the use of BAFF-targeted therapies in SLE.
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影响因子：
4.4
作者：
Chang, Sook Kyung;Mihalcik, Stephen A.;Jelinek, Diane F.
通讯作者：
Jelinek, Diane F.
影响因子：
4.4
作者：
Kyaw, Tin;Tay, Christopher;Toh, Ban-Hock
通讯作者：
Toh, Ban-Hock
影响因子：
4.4
作者：
Hamaguchi, Y;Uchida, J;Tedder, TF
通讯作者：
Tedder, TF
尖端：BAFF通过过渡B细胞的TACI依赖性激活促进自身抗体的产生。
DOI：
10.4049/jimmunol.1600017
发表时间：
2016-05-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Jacobs HM;Thouvenel CD;Leach S;Arkatkar T;Metzler G;Scharping NE;Kolhatkar NS;Rawlings DJ;Jackson SW
通讯作者：
Jackson SW
影响因子：
4.4
作者：
Alexaki, Vassilia-Ismini;Notas, George;Castanas, Elias
通讯作者：
Castanas, Elias