Prevalence and determinants of SARS-CoV-2 vaccine hesitancy in Hong Kong: A population-based survey.
Prevalence and determinants of SARS-CoV-2 vaccine hesitancy in Hong Kong: A population-based survey.
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DOI：
10.1016/j.vaccine.2021.05.036
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发表时间：
2021-06-16
期刊：
影响因子：
5.5
通讯作者：
Lam TH
中科院分区：
文献类型：
--
作者：
Luk TT;Zhao S;Wu Y;Wong JY;Wang MP;Lam TH
尽管针对严重急性呼吸道综合征冠状病毒2（SARS-CoV-2）的疫苗接种是结束冠状病毒病（COVID-19）大流行的最理想解决方案，但人们越来越担心疫苗犹豫会破坏其潜力。我们研究了在香港的中国成年人的代表性样本中接受SARS-CoV-2疫苗接种的意愿及其相关因素。我们于2020年4月对1501名18岁或以上的香港居民（53. 6%为女性）进行了双框架（固定电话和移动的）横断面调查。我们收集了有关SARS-CoV-2疫苗可用时接受SARS-CoV-2疫苗的意愿（是/否/未定）、对COVID-19的知识和看法、吸烟、饮酒和社会人口因素的数据。患病率的估计是加权的性别，年龄和教育的一般人口的香港。总体而言，45.3%（95% CI：42.3-48.4%）的参与者有意愿在SARS-CoV-2疫苗可用时接种，29.2%（26.5-32.1%）尚未决定，25.5%（22.9-28.2%）没有意愿。疫苗犹豫（未决定或无意）的最常见原因是安全性问题（56.5%）。多变量部分比例优势模型显示，男性、年轻人、无慢性疾病者、当前吸烟者和不饮酒者的疫苗犹豫率较高。在调整社会人口统计学和其他因素后，对SARS-CoV-2传播的知识不足（调整后的OR范围为1.27至2.63; P < 0.05）和对COVID-19的感知危险性较低（调整后的OR范围为1.62至2.47; P < 0.001）与疫苗犹豫显著相关。在香港中国成年人的代表性样本中，只有45.3%的参与者打算接种SARS-CoV-2疫苗。疫苗犹豫与对SARS-CoV-2传播的知识不足以及对COVID-19的感知危险较低有关，需要解决这一问题以提高疫苗接种率。
Although vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the most desired solution to end the coronavirus disease (COVID-19) pandemic, there are growing concerns that vaccine hesitancy would undermine its potential. We examined the intention to receive vaccination against SARS-CoV-2 and the associated factors in a representative sample of Chinese adults in Hong Kong. We did a dual-frame (landline and mobile) cross-sectional survey of a random sample of 1501 Hong Kong residents aged 18 years or older (53.6% females) in April 2020. We collected data on the intention to receive SARS-CoV-2 vaccine when it becomes available (yes/ no/ undecided), knowledge and perceptions of COVID-19, smoking, alcohol drinking, and sociodemographic factors. Prevalence estimates were weighted by the sex, age, and education of the general population of Hong Kong. Overall, 45.3% (95% CI: 42.3–48.4%) of the participants had intentions to vaccinate against SARS-CoV-2 when it becomes available, 29.2% (26.5–32.1%) were undecided, and 25.5% (22.9–28.2%) had no intention. The most common reason for vaccine hesitancy (undecided or no intention) was safety concerns (56.5%). Multivariable partial proportional odds model showed higher vaccine hesitancy in males, younger adults, those with no chronic disease, current smokers, and non-alcohol drinkers. After adjusting for sociodemographic and other factors, inadequate knowledge of SARS-CoV-2 transmission (adjusted ORs ranged from 1.27 to 2.63; P < 0.05) and lower perceived danger of COVID-19 (adjusted ORs ranged from 1.62 to 2.47; P < 0.001) were significantly associated with vaccine hesitancy. In a representative sample of Chinese adults in Hong Kong, only 45.3% of the participants intended to vaccinate against SARS-CoV-2 when available. Vaccine hesitancy was associated with inadequate knowledge about SARS-CoV-2 transmission and lower perceived danger of COVID-19, which needed to be addressed to improve vaccination uptake.
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