IRX5 promotes DNA damage repair and activation of hair follicle stem cells.
IRX5 promotes DNA damage repair and activation of hair follicle stem cells.
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IRX5促进DNA损伤修复和毛囊干细胞活化。
DOI：
10.1016/j.stemcr.2023.03.013
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发表时间：
2023-05-09
影响因子：
5.9
通讯作者：
Andersen, Bogi
中科院分区：
文献类型：
--
作者：
Chen, Jefferson K.;Wiedemann, Julie;Nguyen, Ly;Lin, Zhongqi;Tahir, Mahum;Hui, Chi-Chung;Plikus, Maksim V.;Andersen, Bogi
The molecular mechanisms allowing hair follicles to periodically activate their stem cells (HFSCs) are incompletely characterized. Here, we identify the transcription factor IRX5 as a promoter of HFSC activation. Irx5−/− mice have delayed anagen onset, with increased DNA damage and diminished HFSC proliferation. Open chromatin regions form near cell cycle progression and DNA damage repair genes in Irx5−/− HFSCs. DNA damage repair factor BRCA1 is an IRX5 downstream target. Inhibition of FGF kinase signaling partially rescues the anagen delay in Irx5−/− mice, suggesting that the Irx5−/− HFSC quiescent phenotype is partly due to failure to suppress Fgf18 expression. Interfollicular epidermal stem cells also show decreased proliferation and increased DNA damage in Irx5−/−mice. Consistent with a role for IRX5 as a promoter of DNA damage repair, we find that IRX genes are upregulated in many cancer types and that there is a correlation between IRX5 and BRCA1 expression in breast cancer. IRX5 promotes cell cycle progression and DNA damage repair through epigenetic regulation Irx5−/− mice display delayed anagen due to suppression of Fgf-mediated quiescence High IRX5 and BRCA1 gene expression is correlated in breast-invasive carcinoma In this article, Chen and colleagues show that IRX5 is an essential transcription factor for hair follicle stem cell activation.
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影响因子：
23.9
作者：
Joost, Simon;Annusver, Karl;Kasper, Maria
通讯作者：
Kasper, Maria
IRX5 通过 OPN 促进舌鳞状细胞癌中 NF-κ B 信号传导以增加增殖、迁移和侵袭
影响因子：
5.3
作者：
Huang L;Song F;Sun H;Zhang L;Huang C
通讯作者：
Huang C
影响因子：
--
作者：
Geyfman M;Plikus MV;Treffeisen E;Andersen B;Paus R
通讯作者：
Paus R
影响因子：
23.9
作者：
Adam RC;Yang H;Ge Y;Lien WH;Wang P;Zhao Y;Polak L;Levorse J;Baksh SC;Zheng D;Fuchs E
通讯作者：
Fuchs E
影响因子：
2.3
作者：
Kawano M;Umeda S;Yasuda T;Fujita M;Ishikawa A;Imamura T;Imai T;Nakayama F
通讯作者：
Nakayama F