Acoustic stimulation of human medial olivocochlear efferents reduces stimulus-frequency and click-evoked otoacoustic emission delays: Implications for cochlear filter bandwidths.
Acoustic stimulation of human medial olivocochlear efferents reduces stimulus-frequency and click-evoked otoacoustic emission delays: Implications for cochlear filter bandwidths.
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DOI：
10.1016/j.heares.2010.04.009
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发表时间：
2010-08
期刊：
影响因子：
2.8
通讯作者：
Guinan, John J., Jr.
中科院分区：
文献类型：
--
作者：
Francis, Nikolas A.;Guinan, John J., Jr.
过滤理论表明，耳蜗滤器带宽的变化伴随着耳蜗声反应潜伏期的变化。以往的报道表明，用对侧宽带噪声(CBBN)刺激内侧橄榄耳蜗区(MOC)传出信号可以缩短耳声发射(OAE)的延迟。这些延迟的减少与MOC诱导的耳蜗滤波器化是一致的。我们使用刺激频率和短声诱发的OAE(SFOAE和CEOAE)来量化MOC诱导的人类耳蜗过滤器相关延迟的变化，记录了60dBSPL CBBN诱发的MOC活动和不记录MOC活动的情况。从SFOAE相位函数的斜率和500赫兹宽的CEOAE频带波形幅度的互相关测量MOC诱导的延迟变化。从CEOAEs和SFOAEs测量的延迟变化在统计学上是不可区分的。两者在较低频率下都表现出更大的延迟减少(在0.5-2 kHz频率范围内减少了5%)。这些数据表明，中等水平的CBBN的MOC活动使耳蜗过滤器扩大了5%。在心理生理学上，低频时耳声发射延迟0.5ms的变化所暗示的耳蜗反应潜伏期的巨大变化，如果它们在中枢神经系统中不平衡，或者由于双耳的MOC系统产生类似的变化，将对双耳定位产生深远的影响。
Filter theory indicates that changes in cochlear filter bandwidths are accompanied by changes in cochlear response latencies. Previous reports indicate that otoacoustic emission (OAE) delays are reduced by exciting medial olivocochlear (MOC) efferents with contralateral broad-band noise (CBBN). These delay reductions are consistent with MOC-induced widening of cochlear filters. We quantified the MOC-induced changes in human cochlear-filter-related delays using stimulus-frequency and click-evoked OAEs (SFOAE and CEOAEs), recorded with and without MOC activity elicited by 60 dB SPL CBBN. MOC-induced delay changes were measured from the slopes of SFOAE phase functions and from cross-correlation of 500 Hz-wide CEOAE frequency-band waveform magnitudes. The delay changes measured from CEOAEs and SFOAEs were statistically indistinguishable. Both showed greater delay reductions at lower frequencies (a 5% decrease in the 0.5 – 2 kHz frequency region). These data indicate that cochlear filters are widened 5% by the MOC activity from moderate-level CBBN. Psychophysically, the large changes in cochlear response latencies, implied by the 0.5 ms change in OAE delay at low frequencies, would have a profound effect on binaural localization if they were not balanced in the central nervous system, or by the MOC system producing similar changes in both ears.
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影响因子：
2.4
作者：
Guinan, John J., Jr.;Cooper, Nigel P.
通讯作者：
Cooper, Nigel P.
影响因子：
2.8
作者：
GUINAN, JJ;GIFFORD, ML
通讯作者：
GIFFORD, ML
DOI：
10.3109/03005368709076405
发表时间：
1987-01-01
期刊：
British Journal of Audiology
影响因子：
--
作者：
BRAY P;KEMP D
通讯作者：
KEMP D
影响因子：
2.4
作者：
Giraud, AL;Wable, J;CheryCroze, S
通讯作者：
CheryCroze, S
影响因子：
2.4
作者：
Kalluri, Radha;Shera, Christopher A.
通讯作者：
Shera, Christopher A.