Shape Effect of Glyco-Nanoparticles on Macrophage Cellular Uptake and Immune Response.
Shape Effect of Glyco-Nanoparticles on Macrophage Cellular Uptake and Immune Response.
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糖纳米颗粒的形状对巨噬细胞摄取和免疫反应的影响
DOI：
10.1021/acsmacrolett.6b00419
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发表时间：
2016-09-20
影响因子：
7.015
通讯作者：
Chen, Guosong
中科院分区：
文献类型：
--
作者：
Li, Zhen;Sun, Liang;Zhang, Yufei;Dove, Andrew P.;O'Reilly, Rachel K.;Chen, Guosong
The shells of various poly(dl-lactide)-b-poly(acrylic acid) (PDLLA-b-PAA) spherical micelles and poly(l-lactide)-b-poly(acrylic acid) (PLLA-b-PAA) cylindrical micelles were functionalized with mannose to yield glyco-nanoparticles (GNPs) with different shapes and dimensions. All of these GNPs were shown to have good biocompatibility (up to 1 mg/mL). Cellular uptake experiments using RAW 264.7 have shown that the spherical GNPs were internalized to a much greater extent than the cylindrical GNPs and such a phenomenon was attributed to their different endocytosis pathways. It was demonstrated that spherical GNPs were internalized based on clathrin- and caveolin-mediated endocytosis while cylindrical GNPs mainly depended on clathrin-mediated endocytosis. We also found that longer cylindrical GNPs (Ln × Wn = 215 × 47 nm) can induce an inflammatory response (specifically interleukin 6) more efficiently than shorter cylindrical GNPs (Ln × Wn = 99 × 50 nm) and spherical GNPs (Dn = 46 nm).
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影响因子：
4
作者：
Chiodo, Fabrizio;Marradi, Marco;Tefsen, Boris
通讯作者：
Tefsen, Boris
影响因子：
17.1
作者：
Hutter, Eliza;Boridy, Sebastien;Maysinger, Dusica
通讯作者：
Maysinger, Dusica
影响因子：
16.6
作者：
Kikkeri, Raghavendra;Laurino, Paola;Seeberger, Peter H.
通讯作者：
Seeberger, Peter H.
影响因子：
4.6
作者：
Dag, Aydan;Lu, Hongxu;Stenzel, Martina
通讯作者：
Stenzel, Martina
影响因子：
21.8
作者：
Munoz, Antonio;Sigwalt, David;Martin, Nazario
通讯作者：
Martin, Nazario