Augmenter of liver regeneration (ALR) restrains concanavalin A-induced hepatitis in mice.
Augmenter of liver regeneration (ALR) restrains concanavalin A-induced hepatitis in mice.
复制标题
肝再生增强剂 (ALR) 可抑制刀豆球蛋白 A 诱导的小鼠肝炎。
DOI：
10.1016/j.intimp.2016.03.040
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发表时间：
2016-06
期刊：
影响因子：
--
通讯作者：
You S
中科院分区：
文献类型：
--
作者：
Mu M;Zhang Z;Cheng Y;Liu G;Chen X;Wu X;Zhuang C;Liu B;Kong X;You S
肝再生增强因子(ALR)由肝细胞产生和释放，对肝损伤具有细胞保护和免疫调节作用，已被广泛应用于多种实验领域。然而，ALR在刀豆蛋白A(ConA)诱导的肝炎中的作用尚未引起足够的重视。本研究旨在探讨ALR对Con A诱导的肝炎的保护作用及其可能的机制。发现ALR预处理可明显降低血清中ALT和AST的含量。此外，促炎细胞因子、趋化因子和诱导型一氧化氮合酶也受到抑制。ALR预处理后，肝组织中的CD_4~+、CD_8~+T细胞明显减少。此外，我们观察到ALR预处理能够抑制ConA诱导的肝炎中几个信号通路的激活。提示ALR能明显减轻ConA诱导的小鼠肝炎，具有一定的免疫调节作用。
Augmenter of liver regeneration (ALR), produced and released by hepatocytes, has cytoprotective and immunoregulatory effects on liver injury, and has been used in many experimental applications. However, little attention has been paid to the effects of ALR on concanavalin A (Con A)-induced hepatitis. The purpose of this paper is to explore the protective effect of ALR on Con A-induced hepatitis and elucidate potential mechanisms. We found that the ALR pretreatment evidently reduced the amount of ALT and AST in serum. In addition, pro-inflammatory cytokines, chemokines and iNOS were suppressed. ALR pretreatment also decreased CD4+, CD8+T cell infiltration in liver. Besides, we observed that ALR pretreatment was capable of suppressing the activation of several signaling pathways in Con A-induced hepatitis. These findings suggest that ALR can obviously weaken Con A-induced hepatitis and ALR has some certain immune regulation function.
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DOI：
10.1084/jem.179.5.1529
发表时间：
1994-05-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Mizuhara H;O'Neill E;Seki N;Ogawa T;Kusunoki C;Otsuka K;Satoh S;Niwa M;Senoh H;Fujiwara H
通讯作者：
Fujiwara H
DOI：
10.1186/1755-1536-5-10
发表时间：
2012-07-09
期刊：
Fibrogenesis & tissue repair
影响因子：
--
作者：
Gandhi CR
通讯作者：
Gandhi CR
DOI：
10.1016/j.jss.2013.02.033
发表时间：
2013-08
期刊：
The Journal of surgical research
影响因子：
--
作者：
Kang Yang;Chengyou Du;Yong Cheng;Yue Li;J. Gong;Zuojin Liu
通讯作者：
Kang Yang;Chengyou Du;Yong Cheng;Yue Li;J. Gong;Zuojin Liu
影响因子：
3.7
作者：
Lv K;Zhang Y;Zhang M;Zhong M;Suo Q
通讯作者：
Suo Q
粉防己碱通过抑制 NF-kappaB 激活来保护小鼠免受伴刀豆球蛋白 A 诱导的肝炎。
影响因子：
4.4
作者：
Feng, Dechun;Mei, Yunhua;Xu, Lingyun
通讯作者：
Xu, Lingyun