HLA-DRB1 and HLA-DQB1 polymorphisms in Pacific Islands populations.
HLA-DRB1 and HLA-DQB1 polymorphisms in Pacific Islands populations.
复制标题
太平洋岛屿人群中的 HLA-DRB1 和 HLA-DQB1 多态性。
作者：
Z. Velickovic;B. Delahunt;J. Carter
在来自库克群岛、萨摩亚、托克劳和汤加的四个太平洋岛屿人群中调查了HLA-DRB 1和HLA-DQB 1基因的等位基因频率分布。HLA-DRB 1和HLA-DQB 1基因座的多样性有限。观察到五个HLA-DRB 1等位基因是所有研究的太平洋岛屿人群中最常见的。HLA-DRB1*0403、HLA-DRB1*08032、HLA-DRB1*09012、HLA-DRB1*11011和HLA-DRB1*1201。库克群岛人的低频DRB 1等位基因数量最多，其次是萨摩亚人、托克劳人和汤加人，其中大部分可能归因于报告的非波利尼西亚混血。最常见的DQB 1等位基因在研究的四个太平洋岛屿人口是等位基因HLA-DQB 1 *03011，HLA-DQB 1 *0302和HLA-DQB 1 *03032以及HLA-DQB 1 *05031和HLA-DQB 1 *06011的DQ 3亚群。库克群岛人HLA-DQB 1等位基因频率最高，分布与HLA-DRB 1等位基因频率相似。虽然一般来说，DRB 1和DQB 1的纯合性值低于中性情况下的预期值，但在汤加人、萨摩亚人和托克劳人中观察到DQB 1基因座的统计学显著性，在汤加人中观察到DRB 1基因座的统计学显著性。托克劳人的等位基因频率分布与其他三个群体相比存在差异。DRB 1和DQB 1等位基因频率的主成分分析也证明了这一点，该分析将托克劳人口与库克群岛人、汤加人和萨摩亚人区分开来。在系统发育树中，汤加人和萨摩亚人与其他波利尼西亚人是分开的。观察到的等位基因和单倍型频率被认为是在协议与以前发表的HLA-DRB和HLA-DQB波利尼西亚人的数据。
Allele frequency distributions of the HLA-DRB1 and HLA-DQB1 genes were investigated in four Pacific Islands populations from the Cook Islands, Samoa, Tokelau and Tonga. Limited diversity was observed for both the HLA-DRB1 and HLA-DQB1 loci. Five HLA-DRB1 alleles were observed to be the most frequent amongst all the studied Pacific Islands populations. They were: HLA-DRB1*0403, HLA-DRB1*08032, HLA-DRB1*09012, HLA-DRB1*11011 and HLA-DRB1*1201. Cook Islanders had the largest number of low frequency DRB1 alleles followed by Samoans, Tokelauans and Tongans, most of which may be attributed to reported non-Polynesian admixture. The most frequently observed DQB1 alleles in the four studied Pacific Islands populations were those of the DQ3 subgroup of alleles HLA-DQB1*03011, HLA-DQB1*0302 and HLA-DQB1*03032 as well as HLA-DQB1*05031 and HLA-DQB1*06011. Cook Islanders had the highest number of rare HLA-DQB1 alleles, the distibution being similar to that of the HLA-DRB1 allele. While, in general, the values of homozygosity for DRB1 and DQB1 were observed to be lower then expected under neutrality, a statistical significance was observed in Tongans, Samoans and Tokelauans for the DQB1 locus and in Tongans for the DRB1 locus. Differences were observed between allele frequency distributions for Tokelauans compared to the other three populations. This was also demonstrated by principal component analysis of DRB1 and DQB1 allele frequencies, which separated the Tokelauan population from Cook Islanders, Tongans and Samoans. Tongans and Samoans were separate from the other Polynesian populations in the phylogenetic trees. Observed allele and haplotype frequencies were found to be in agreement with previously published HLA-DRB and HLA-DQB Polynesian data.
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DOI：
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影响因子：
--
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影响因子：
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