The Role of CD44 in Disease Pathophysiology and Targeted Treatment.
The Role of CD44 in Disease Pathophysiology and Targeted Treatment.
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CD44 在疾病病理生理学和靶向治疗中的作用。
DOI：
10.3389/fimmu.2015.00182
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发表时间：
2015
影响因子：
7.3
通讯作者：
Lokeshwar VB
中科院分区：
文献类型：
--
作者：
Jordan AR;Racine RR;Hennig MJ;Lokeshwar VB
细胞表面糖蛋白CD44参与许多重要的生理功能，包括细胞增殖、粘附、迁移、造血和淋巴细胞活化。CD44的多种生理活性表现在癌症、关节炎、细菌和病毒感染、肺间质性疾病、血管疾病和伤口愈合等多种疾病的病理中。这种生物活性的多样性是通过复杂的选择性剪接、翻译后修饰（例如N-糖基化和o -糖基化）、与许多不同配体的相互作用以及CD44在细胞表面的丰度和空间分布而产生的各种不同的CD44异构体所赋予的。细胞外基质糖胺聚糖透明质酸（HA）是CD44的主要配体。本文综述了CD44-透明质酸依赖和独立的CD44信号以及CD44- ha相互作用在各种病理生理中的作用。该综述还讨论了利用CD44-HA相互作用直接靶向或药物递送的新治疗策略的最新进展。
The cell-surface glycoprotein CD44 is involved in a multitude of important physiological functions including cell proliferation, adhesion, migration, hematopoiesis, and lymphocyte activation. The diverse physiological activity of CD44 is manifested in the pathology of a number of diseases including cancer, arthritis, bacterial and viral infections, interstitial lung disease, vascular disease, and wound healing. This diversity in biological activity is conferred by both a variety of distinct CD44 isoforms generated through complex alternative splicing, posttranslational modifications (e.g., N- and O-glycosylation), interactions with a number of different ligands, and the abundance and spatial distribution of CD44 on the cell surface. The extracellular matrix glycosaminoglycan hyaluronic acid (HA) is the principle ligand of CD44. This review focuses both CD44-hyaluronan dependent and independent CD44 signaling and the role of CD44–HA interaction in various pathophysiologies. The review also discusses recent advances in novel treatment strategies that exploit the CD44–HA interaction either for direct targeting or for drug delivery.
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影响因子：
14
作者：
Ganesh, Shanthi;Iyer, Arun K.;Morrissey, David V.;Amiji, Mansoor M.
通讯作者：
Amiji, Mansoor M.
影响因子：
11.2
作者：
Benitez A;Yates TJ;Lopez LE;Cerwinka WH;Bakkar A;Lokeshwar VB
通讯作者：
Lokeshwar VB
影响因子：
37.3
作者：
Chen L;Bourguignon LY
通讯作者：
Bourguignon LY
影响因子：
9.7
作者：
Dicker, Kevin T.;Gurski, Lisa A.;Pradhan-Bhatt, Swati;Witt, Robert L.;Farach-Carson, Mary C.;Jia, Xinqiao
通讯作者：
Jia, Xinqiao
影响因子：
5.2
作者：
Chung SS;Giehl N;Wu Y;Vadgama JV
通讯作者：
Vadgama JV