Hyaluronan: a simple polysaccharide with diverse biological functions.
Hyaluronan: a simple polysaccharide with diverse biological functions.
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DOI：
10.1016/j.actbio.2013.12.019
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发表时间：
2014-04
影响因子：
9.7
通讯作者：
Jia, Xinqiao
中科院分区：
文献类型：
--
作者：
Dicker, Kevin T.;Gurski, Lisa A.;Pradhan-Bhatt, Swati;Witt, Robert L.;Farach-Carson, Mary C.;Jia, Xinqiao
透明质酸（HA）是一种线性多糖，具有D-葡萄糖醛酸和N-乙酰基-D-葡萄糖胺的二糖重复序列。它在进化上是保守的，并且在细胞外基质（ECM）、细胞表面甚至细胞内大量表达。作为一种简单的多糖，HA表现出惊人的生物学功能。HA与各种蛋白质或蛋白聚糖相互作用以组织ECM并维持组织稳态。HA独特的物理和机械性质有助于维持组织水合作用、介导溶质通过细胞外间隙扩散以及润滑某些组织。HA的多种生物学功能通过其与基质组分和驻留细胞的复杂相互作用而显现。HA与细胞表面受体的结合激活调节细胞功能、组织发育、炎症、伤口愈合和肿瘤进展和转移的各种信号传导途径。利用HA固有的生物相容性和生物降解性，以及其对化学修饰的敏感性，研究人员已经开发出各种具有广阔临床潜力的HA基生物材料和组织构建体。在这篇文章中，我们从基质生物学的角度说明HA的特性，首先介绍HA的生物合成和生物降解的基本原理，以及HA与各种蛋白质和蛋白聚糖的相互作用。我们接下来强调HA在生理和病理状态中的作用，包括形态发生、伤口愈合和肿瘤转移。深入了解HA在各种生理过程中的作用机制，可以为复杂组织和组织模型的工程化提供新的见解和工具。
Hyaluronan (HA) is a linear polysaccharide with disaccharide repeats of D-glucuronic acid and N-acetyl-D-glucosamine. It is evolutionary conserved and abundantly expressed in the extracellular matrix (ECM), on the cell surface and even inside cells. Being a simple polysaccharide, HA exhibits an astonishing array of biological functions. HA interacts with various proteins or proteoglycans to organize the ECM and to maintain tissue homeostasis. The unique physical and mechanical properties of HA contribute to the maintenance of tissue hydration, the mediation of solute diffusion through the extracellular space and the lubrication of certain tissues. The diverse biological functions of HA are manifested through its complex interactions with matrix components and resident cells. Binding of HA with cell surface receptors activates various signaling pathways that regulate cell function, tissue development, inflammation, wound healing and tumor progression and metastasis. Taking advantage of the inherent biocompatibility and biodegradability of HA, as well as its susceptibility to chemical modification, researchers have developed various HA-based biomaterials and tissue constructs with promising and broad clinical potential. In this article, we illustrate the properties of HA from a matrix biology perspective by first introducing principles underlying the biosynthesis and biodegradation of HA, as well as the interactions of HA with various proteins and proteoglycans. We next highlight the roles of HA in physiological and pathological states, including morphogenesis, wound healing and tumor metastasis. A deeper understanding of the mechanisms underlying the roles of HA in various physiological processes can provide new insights and tools for the engineering of complex tissues and tissue models.
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影响因子：
2.4
作者：
Chan, RW;Titze, IR
通讯作者：
Titze, IR
影响因子：
4.8
作者：
Bourguignon, LYW;Gilad, E;Peyrollier, K
通讯作者：
Peyrollier, K
影响因子：
7.8
作者：
Banerji, S;Ni, J;Wang, S X;Clasper, S;Su, J;Tammi, R;Jones, M;Jackson, D G
通讯作者：
Jackson, D G
DOI：
10.1074/jbc.m113.477422
发表时间：
2013-10-11
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Baranova NS;Foulcer SJ;Briggs DC;Tilakaratna V;Enghild JJ;Milner CM;Day AJ;Richter RP
通讯作者：
Richter RP
影响因子：
3.4
作者：
Chan, RW;Gray, SD;Titze, IR
通讯作者：
Titze, IR