Lycopene enhances antioxidant enzyme activities and immunity function in N-methyl-N'-nitro-N-nitrosoguanidine-enduced gastric cancer rats.
Lycopene enhances antioxidant enzyme activities and immunity function in N-methyl-N'-nitro-N-nitrosoguanidine-enduced gastric cancer rats.
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番茄红素增强了N-甲基N'N'N'N'N'N'Intro-n-硝基瓜烷二烷丁胺剂量胃癌大鼠的抗氧化剂活性和免疫功能。
DOI：
10.3390/ijms12053340
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发表时间：
2011
影响因子：
5.6
通讯作者：
Wu XG
中科院分区：
文献类型：
--
作者：
Luo C;Wu XG
为了探讨番茄红素的抗癌作用，我们研究了番茄红素对n -甲基-n ' -硝基-n -亚硝基胍（MNNG）诱导的胃癌大鼠氧化损伤和免疫活性的影响。这些动物被分成五组。ⅰ组为正常对照组，口服玉米油20周。II组小鼠于第0、14天灌胃以200 mg/kg体重的MNNG诱导，每3天灌胃1 mL饱和NaCl，连续4周至实验结束。III、IV和V组从MNNG诱导第6周开始（与II组相同）至试验期结束，分别给予番茄红素（50、100和150 mg/kg体重，溶解于玉米油中）处理。在MNNG存在下，与正常对照大鼠相比，处理大鼠的MDA和免疫水平显著升高，而酶（SOD、CAT和GPx）抗氧化活性降低。与II组相比，番茄红素对胃癌诱导大鼠的氧化还原状态和免疫活性有很大的上调，从而降低了癌症的风险。我们认为，番茄红素处理对抗氧化剂和免疫的上调可能与胃癌的抗癌作用有关。
To investigate anticancer effect of lycopene, we examined the effects of lycopene on the oxidative injury and immunity activities of N-methyl-N′-nitro-N-nitrosoguanidine (MNNG)-induced gastric cancer rats. The animals were divided into five groups. Group I served as the normal control and was given corn oil orally for 20 weeks. Group II were induced with MNNG 200 mg/kg body weight by oral gavage at days 0 and 14, and saturated NaCl (1 mL per rats) was given once every three days for four weeks until the end of the experimental period. Group III, IV and V were posttreated with lycopene (50, 100 and 150 mg/kg body weight, dissolved in corn oil) from the sixth week of MNNG (as in group II) induction up to the end of the experimental period. In the presence of MNNG, MDA and immunity levels were significantly increased, whereas enzymatic (SOD, CAT, and GPx) antioxidant activities were decreased in the treated rats compared with normal control rats. Administration of lycopene to gastric carcinoma-induced rats largely up-regulated the redox status and immunity activities to decrease the risk of cancer compared to group II. We conclude that up-regulation of antioxidants and immunity by lycopene treatment might be responsible for the anticancer effect in gastric carcinoma.
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影响因子：
4.8
作者：
DeBoer, Mark D.;Zhu, Xin Xia;Marks, Daniel L.
通讯作者：
Marks, Daniel L.
DOI：
10.1093/gerona/62.3.308
发表时间：
2007-03-01
影响因子：
5.1
作者：
Akbaraly, N. Tasnime;Faure, Henri;Berr, Claudine
通讯作者：
Berr, Claudine
影响因子：
3.2
作者：
Heber, D;Lu, QY
通讯作者：
Lu, QY
影响因子：
10.3
作者：
Boileau, TWM;Liao, ZM;Clinton, SK
通讯作者：
Clinton, SK
影响因子：
9.7
作者：
Guttenplan, JB;Chen, M;Cohen, LA
通讯作者：
Cohen, LA