Efficacy of oral cryotherapy on oral mucositis prevention in patients with hematological malignancies undergoing hematopoietic stem cell transplantation: a meta-analysis of randomized controlled trials.
Efficacy of oral cryotherapy on oral mucositis prevention in patients with hematological malignancies undergoing hematopoietic stem cell transplantation: a meta-analysis of randomized controlled trials.
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口腔冷冻疗法对接受造血干细胞移植的血液恶性肿瘤患者预防口腔粘膜炎的功效：随机对照试验的荟萃分析。
DOI：
10.1371/journal.pone.0128763
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Gao C
中科院分区：
文献类型：
--
作者：
Wang L;Gu Z;Zhai R;Zhao S;Luo L;Li D;Zhao X;Wei H;Pang Z;Wang L;Liu D;Wang Q;Gao C
关于口腔冷冻疗法是否可以预防接受造血干细胞移植（HSCT）的血液恶性肿瘤患者的口腔粘膜炎（OM）存在争议。本荟萃分析的目的是评估口服冷冻疗法对接受 HSCT 的血液恶性肿瘤患者预防 OM 的功效。 PubMed 和 Cochrane 图书馆的检索截止至 2014 年 10 月。纳入了比较口服冷冻疗法与不治疗或其他干预措施对接受 HSCT 患者的 OM 效果的随机对照试验 (RCT)。主要结局是 OM 的发生率、严重程度和持续时间。次要结局包括镇痛药使用时间、全肠外营养（TPN）使用时间和住院时间。纳入了 7 项随机对照试验，涉及 8 篇文章，分析了 458 名患者。口服冷冻疗法显着降低了严重 OM 的发生率（RR = 0.52，95% CI = 0.27 至 0.99）和 OM 严重程度（SMD = -2.07，95% CI = -3.90 至 -0.25）。此外，TPN的使用时间和住院时间也显着缩短（分别为SMD = -0.56，95% CI = -0.92至-0.19；SMD = -0.44，95% CI = -0.76至-0.13）。然而，OM 和镇痛药使用持续时间的汇总结果不确定（分别为 SMD = -0.13，95% CI = -0.41 至 0.15；SMD = -1.15，95% CI = -2.57 至 0.27）。对于接受 HSCT 的患者来说，口服冷冻疗法是一种易于应用且经济有效的 OM 预防方法。
Controversy exists regarding whether oral cryotherapy can prevent oral mucositis (OM) in patients with hematological malignancies undergoing hematopoietic stem cell transplantation (HSCT). The aim of the present meta-analysis was to evaluate the efficacy of oral cryotherapy for OM prevention in patients with hematological malignancies undergoing HSCT. PubMed and the Cochrane Library were searched through October 2014. Randomized controlled trials (RCTs) comparing the effect of oral cryotherapy with no treatment or with other interventions for OM in patients undergoing HSCT were included. The primary outcomes were the incidence, severity, and duration of OM. The secondary outcomes included length of analgesic use, total parenteral nutrition (TPN) use, and length of hospital stay. Seven RCTs involving eight articles analyzing 458 patients were included. Oral cryotherapy significantly decreased the incidence of severe OM (RR = 0.52, 95% CI = 0.27 to 0.99) and OM severity (SMD = -2.07, 95% CI = -3.90 to -0.25). In addition, the duration of TPN use and the length of hospitalization were markedly reduced (SMD = -0.56, 95% CI = -0.92 to -0.19; SMD = -0.44, 95% CI = -0.76 to -0.13; respectively). However, the pooled results were uncertain for the duration of OM and analgesic use (SMD = -0.13, 95% CI = -0.41 to 0.15; SMD = -1.15, 95% CI = -2.57 to 0.27; respectively). Oral cryotherapy is a readily applicable and cost-effective prophylaxis for OM in patients undergoing HSCT.
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影响因子：
3.3
作者：
Eduardo, Fernanda de Paula;Bezinelli, Leticia Mello;Correa, Luciana
通讯作者：
Correa, Luciana
影响因子：
4.7
作者：
Salvador, Prisco;Azusano, Cristina;Howell, Doris
通讯作者：
Howell, Doris
影响因子：
4.8
作者：
Lilleby, K.;Garcia, P.;Bensinger, W.
通讯作者：
Bensinger, W.
影响因子：
3.1
作者：
Batlle, Montserrat;Morgades, Mireia;Ribera, Josep-Maria
通讯作者：
Ribera, Josep-Maria
影响因子：
2.2
作者：
Sato, Atsushi;Saisho-Hattori, Takako;Imaizumi, Masue
通讯作者：
Imaizumi, Masue