Emergence of Livestock-Associated Methicillin-Resistant Staphylococcus aureus Bloodstream Infections in Denmark.
Emergence of Livestock-Associated Methicillin-Resistant Staphylococcus aureus Bloodstream Infections in Denmark.
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DOI：
10.1093/cid/cix504
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发表时间：
2017-10-01
期刊：
影响因子：
--
通讯作者：
Danish MRSA Study Group
中科院分区：
文献类型：
--
作者：
Larsen J;Petersen A;Larsen AR;Sieber RN;Stegger M;Koch A;Aarestrup FM;Price LB;Skov RL;Danish MRSA Study Group
2010-2015年期间，牲畜相关耐甲氧西林金黄色葡萄球菌（LA-MRSA）CC 398是丹麦菌血症的一个日益增加的原因。大多数患者生活在农村地区，但没有接触牲畜。全基因组测序支持丹麦猪是人类LA-MRSA CC 398感染的最可能来源。家畜相关耐甲氧西林金黄色葡萄球菌克隆复合物398（LA-MRSA CC 398）在丹麦和其他欧洲养猪国家引起越来越多的皮肤和软组织感染（SSTI）。然而，其对MRSA血流感染（BSI）的影响尚未得到充分研究。我们调查了2010-2015年期间所有LA-MRSA CC 398 BSI人类病例的临床流行病学。将LA-MRSA CC 398 BSI病例与其他类型MRSA引起的BSI病例和LA-MRSA CC 398引起的SSTI病例进行比较。全基因组序列分析用于评估来自丹麦猪的LA-MRSA CC 398分离株与BSI和SSTI病例之间的系统发育关系。LA-MRSA CC 398 BSI和SSTI的数量逐年增加，在2014年达到峰值，当时LA-MRSA CC 398占所有MRSA BSI和SSTI的16%（7/44）和21%（211/985），分别相当于每100万人年1.2和37.4例BSI和SSTI。大多数LA-MRSA CC 398 BSI患者没有接触过牲畜，尽管他们往往生活在农村地区。LA-MRSA CC 398在没有牲畜接触的人群中引起每1000例SSTI中有24.3例BSI，这与其他类型MRSA的比例相似。全基因组序列分析表明，大多数BSI和SSTI分离株与丹麦猪分离株关系密切。该研究表明，LA-MRSA CC 398 BSI数量的增加与LA-MRSA CC 398 SSTI的更大波动和猪储库的扩大平行发生。
Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) CC398 was an increasing cause of bacteremia in Denmark during 2010–2015. Most patients lived in rural areas but had no contact to livestock. Whole-genome sequencing supported that Danish pigs are the most likely source of human LA-MRSA CC398 infections. Livestock-associated methicillin-resistant Staphylococcus aureus clonal complex 398 (LA-MRSA CC398) is causing an increasing number of skin and soft tissue infections (SSTIs) in Denmark and other European countries with industrial pig production. Yet, its impact on MRSA bloodstream infections (BSIs) has not been well studied. We investigated the clinical epidemiology of all human cases of LA-MRSA CC398 BSI during 2010–2015. Cases of LA-MRSA CC398 BSI were compared to cases of BSI caused by other types of MRSA and cases of SSTI caused by LA-MRSA CC398. Whole-genome sequence analysis was used to assess the phylogenetic relationship among LA-MRSA CC398 isolates from Danish pigs and cases of BSI and SSTI. The number of LA-MRSA CC398 BSIs and SSTIs increased over the years, peaking in 2014, when LA-MRSA CC398 accounted for 16% (7/44) and 21% (211/985) of all MRSA BSIs and SSTIs, corresponding to 1.2 and 37.4 cases of BSI and SSTI per 1000000 person-years, respectively. Most patients with LA-MRSA CC398 BSI had no contact to livestock, although they tended to live in rural areas. LA-MRSA CC398 caused 24.3 BSIs per 1000 SSTIs among people with no livestock contact, which is similar to the ratio observed for other types of MRSA. Whole-genome sequence analysis showed that most of the BSI and SSTI isolates were closely related to Danish pig isolates. This study demonstrates that the increasing number of LA-MRSA CC398 BSIs occurred in parallel with a much larger wave of LA-MRSA CC398 SSTIs and an expanding pig reservoir.
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影响因子：
6.4
作者：
Price LB;Stegger M;Hasman H;Aziz M;Larsen J;Andersen PS;Pearson T;Waters AE;Foster JT;Schupp J;Gillece J;Driebe E;Liu CM;Springer B;Zdovc I;Battisti A;Franco A;Zmudzki J;Schwarz S;Butaye P;Jouy E;Pomba C;Porrero MC;Ruimy R;Smith TC;Robinson DA;Weese JS;Arriola CS;Yu F;Laurent F;Keim P;Skov R;Aarestrup FM
通讯作者：
Aarestrup FM
影响因子：
11.8
作者：
Nielsen RT;Kemp M;Holm A;Skov MN;Detlefsen M;Hasman H;Aarestrup FM;Kaas RS;Nielsen JB;Westh H;Kolmos HJ
通讯作者：
Kolmos HJ
影响因子：
4.5
作者：
Verkade, Erwin;Bosch, Thijs;Kluytmans, Jan
通讯作者：
Kluytmans, Jan
影响因子：
11.8
作者：
van Cleef BA;Monnet DL;Voss A;Krziwanek K;Allerberger F;Struelens M;Zemlickova H;Skov RL;Vuopio-Varkila J;Cuny C;Friedrich AW;Spiliopoulou I;Pászti J;Hardardottir H;Rossney A;Pan A;Pantosti A;Borg M;Grundmann H;Mueller-Premru M;Olsson-Liljequist B;Widmer A;Harbarth S;Schweiger A;Unal S;Kluytmans JA
通讯作者：
Kluytmans JA
DOI：
10.1093/cid/ciw552
发表时间：
2016-12-01
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Grøntvedt CA;Elstrøm P;Stegger M;Skov RL;Skytt Andersen P;Larssen KW;Urdahl AM;Angen Ø;Larsen J;Åmdal S;Løtvedt SM;Sunde M;Bjørnholt JV
通讯作者：
Bjørnholt JV