Methicillin-Resistant Staphylococcus aureus CC398 in Humans and Pigs in Norway: A "One Health" Perspective on Introduction and Transmission.
Methicillin-Resistant Staphylococcus aureus CC398 in Humans and Pigs in Norway: A "One Health" Perspective on Introduction and Transmission.
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DOI：
10.1093/cid/ciw552
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发表时间：
2016-12-01
期刊：
影响因子：
--
通讯作者：
Bjørnholt JV
中科院分区：
文献类型：
--
作者：
Grøntvedt CA;Elstrøm P;Stegger M;Skov RL;Skytt Andersen P;Larssen KW;Urdahl AM;Angen Ø;Larsen J;Åmdal S;Løtvedt SM;Sunde M;Bjørnholt JV
这项研究提供了强有力的新证据，证明人类可能将耐甲氧西林金黄色葡萄球菌CC 398引入封闭的猪群;它还证明了严格的控制和根除措施是有效的，并防止了从猪场传播到一般人群。背景：新出现的与家畜相关的耐甲氧西林金黄色葡萄球菌（MRSA）持续存在于家畜群体中，是传播给人类的储存库。 了解传入和进一步传播的途径对于控制这种对人类健康的威胁至关重要。方法：纳入了2008年至2014年期间挪威人和猪中报告的所有牲畜相关MRSA（CC 398）病例。 在广泛的疫情调查期间收集了数据，包括接触者追踪和严格的监测。对所有人类病例和猪场的分离株进行全基因组测序，以支持和扩大流行病学调查结果。国家战略还包括在养猪场一级的“搜索和销毁”政策。结果：确定了三个爆发聚集性疫情，包括26个养猪场、2个屠宰场和36人。 初次引入可能通过人传人发生在3个母猪场，其次传播到其他猪场，主要是通过动物贸易，其次是通过人或牲畜卡车。所有从人类分离的MRSA CC 398与疫情没有流行病学联系，与疫情集群内的分离株在遗传上不同，表明对一般人群的传播有限。结论：本研究确定了MRSA CC 398引入和传播的可预防途径：人类职业接触、猪贸易和牲畜运输车辆。 这些发现对于保持猪群免受耐甲氧西林金黄色葡萄球菌感染至关重要，并且从“同一个健康”的角度来看，防止养猪场成为耐甲氧西林金黄色葡萄球菌传播给人类的宿主。
This study provides strong, novel evidence that humans may introduce methicillin-resistant Staphylococcus aureus CC398 into closed pig populations; it also demonstrates that stringent control and eradication measures were effective and prevented dissemination from pig farms to the general human population. Background. Emerging livestock-associated methicillin-resistant Staphylococcus aureus (MRSA) persist in livestock populations and represent a reservoir for transmission to humans. Understanding the routes of introduction and further transmission is crucial to control this threat to human health. Methods. All reported cases of livestock-associated MRSA (CC398) in humans and pigs in Norway between 2008 and 2014 were included. Data were collected during an extensive outbreak investigation, including contact tracing and stringent surveillance. Whole-genome sequencing of isolates from all human cases and pig farms was performed to support and expand the epidemiological findings. The national strategy furthermore included a “search-and-destroy” policy at the pig farm level. Results. Three outbreak clusters were identified, including 26 pig farms, 2 slaughterhouses, and 36 humans. Primary introductions likely occurred by human transmission to 3 sow farms with secondary transmission to other pig farms, mainly through animal trade and to a lesser extent via humans or livestock trucks. All MRSA CC398 isolated from humans without an epidemiological link to the outbreaks were genetically distinct from isolates within the outbreak clusters indicating limited dissemination to the general population. Conclusions. This study identified preventable routes of MRSA CC398 introduction and transmission: human occupational exposure, trade of pigs and livestock transport vehicles. These findings are essential for keeping pig populations MRSA free and, from a “One Health” perspective, preventing pig farms from becoming reservoirs for MRSA transmission to humans.
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影响因子：
11.8
作者：
van Cleef BA;Monnet DL;Voss A;Krziwanek K;Allerberger F;Struelens M;Zemlickova H;Skov RL;Vuopio-Varkila J;Cuny C;Friedrich AW;Spiliopoulou I;Pászti J;Hardardottir H;Rossney A;Pan A;Pantosti A;Borg M;Grundmann H;Mueller-Premru M;Olsson-Liljequist B;Widmer A;Harbarth S;Schweiger A;Unal S;Kluytmans JA
通讯作者：
Kluytmans JA
影响因子：
3.2
作者：
Verkade, Erwin;Kluytmans, Jan
通讯作者：
Kluytmans, Jan
影响因子：
3.3
作者：
通讯作者：
--
影响因子：
3.7
作者：
Köck R;Schaumburg F;Mellmann A;Köksal M;Jurke A;Becker K;Friedrich AW
通讯作者：
Friedrich AW
在1999年至2011年，丹麦无牲畜接触的患者中，抗甲基肽的金黄色葡萄球菌CC398是疾病的越来越多的原因。
DOI：
10.2807/1560-7917.es.2015.20.37.30021
发表时间：
2015
期刊：
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
影响因子：
--
作者：
Larsen J;Petersen A;Sørum M;Stegger M;van Alphen L;Valentiner-Branth P;Knudsen LK;Larsen LS;Feingold B;Price LB;Andersen PS;Larsen AR;Skov RL
通讯作者：
Skov RL