The effect of blue-blocking intraocular lenses on circadian biological rhythm: protocol for a randomised controlled trial (CLOCK-IOL colour study).
The effect of blue-blocking intraocular lenses on circadian biological rhythm: protocol for a randomised controlled trial (CLOCK-IOL colour study).
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蓝块的眼内镜头对昼夜节律生物节奏的影响：随机对照试验的方案（时钟彩色研究）。
DOI：
10.1136/bmjopen-2015-007930
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发表时间：
2015-05-12
期刊：
影响因子：
2.9
通讯作者：
Ogata N
中科院分区：
文献类型：
--
作者：
Nishi T;Saeki K;Obayashi K;Miyata K;Tone N;Tsujinaka H;Yamashita M;Masuda N;Mizusawa Y;Okamoto M;Hasegawa T;Maruoka S;Ueda T;Kojima M;Matsuura T;Kurumatani N;Ogata N
蓝光信息在外部环境中同步内部生物节律方面发挥着重要作用。昼夜节律失调与睡眠障碍、肥胖、糖尿病、抑郁、缺血性心脏病、中风和癌症的风险增加有关。同时，蓝光对视网膜造成光化学损伤，可能与年龄相关性黄斑变性（AMD）有关。目前，透明人工晶状体（IOL）和蓝色阻挡人工晶状体都广泛用于白内障手术;目前缺乏随机对照试验来确定是否应该使用透明人工晶状体或蓝色阻挡人工晶状体。这项随机对照试验将招募1000名白内障患者，并将他们以1：1的比例随机分配接受透明IOL或蓝光阻断IOL。主要结局是死亡率和心血管疾病、癌症和AMD的发病率。次要结果是空腹血糖、甘油三酯、胆固醇、糖化血红蛋白、睡眠质量、日间嗜睡抑郁症状、光敏感性、身体活动的昼夜节律、手腕皮肤温度和尿褪黑激素代谢产物。主要结局将随访至术后20年，次要结局将在基线和术后1年进行评估。 已获得奈良医科大学机构审查委员会的伦理批准（编号13-032）。这项研究的结果将通过同行评议的出版物、科学会议和大学医院医学信息网络临床试验注册处（UMIN-CTR）主页传达给医疗保健专业人员、参与者和公众。UMIN000014680。
Blue light information plays an important role in synchronising internal biological rhythm within the external environment. Circadian misalignment is associated with the increased risk of sleep disturbance, obesity, diabetes mellitus, depression, ischaemic heart disease, stroke and cancer. Meanwhile, blue light causes photochemical damage to the retina, and may be associated with age-related macular degeneration (AMD). At present, clear intraocular lenses (IOLs) and blue-blocking IOLs are both widely used for cataract surgery; there is currently a lack of randomised controlled trials to determine whether clear or blue-blocking IOLs should be used. This randomised controlled trial will recruit 1000 cataract patients and randomly allocate them to receive clear IOLs or blue-blocking IOLs in a ratio of 1:1. The primary outcomes are mortality and the incidence of cardiovascular disease, cancer and AMD. Secondary outcomes are fasting plasma glucose, triglycerides, cholesterol, glycated haemoglobin, sleep quality, daytime sleepiness depressive symptoms, light sensitivity, the circadian rhythm of physical activity, wrist skin temperature and urinary melatonin metabolite. Primary outcomes will be followed until 20 years after surgery, and secondary outcomes will be assessed at baseline and 1 year after surgery. Ethical approval has been obtained from the Institutional Review Board of Nara Medical University (No. 13-032). The findings of this study will be communicated to healthcare professionals, participants and the public through peer-reviewed publications, scientific conferences and the University Hospital Medical Information Network Clinical Trials Registry (UMIN-CTR) home page. UMIN000014680.
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影响因子：
6.3
作者：
Bara, Ana-Claudia;Arber, Sara
通讯作者：
Arber, Sara
影响因子：
2
作者：
Fraser, Michelle L.;Meuleners, Lynn B.;Morlet, Nigel
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Morlet, Nigel
影响因子：
64.8
作者：
Dacey, DM;Liao, HW;Gamlin, PD
通讯作者：
Gamlin, PD
影响因子：
4
作者：
Asplund, R;Lindblad, BE
通讯作者：
Lindblad, BE
影响因子：
5.6
作者：
JOHNS, MW
通讯作者：
JOHNS, MW