Improved selection of patients for programmed ventricular stimulation by frequency analysis of signal-averaged electrocardiograms.

Improved selection of patients for programmed ventricular stimulation by frequency analysis of signal-averaged electrocardiograms.
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通过信号平均心电图的频率分析,改进了对程序性心室刺激的患者的选择。

DOI:
10.1161/01.cir.73.4.675
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发表时间:
1986
期刊:
影响因子:
37.8
通讯作者:
Cain,ME
Cain,ME
中科院分区:
医学1区
文献类型:
--
作者:
Lindsay,BD;Ambos,HD;Schechtman,KB;Cain,ME

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需要改进对疑似持续性室性心动过速(VT)患者进行程控心室刺激的选择。为了确定频率分析是否检测到可能诱发持续性VT的患者,我们首先获得了20例自发性持续性VT患者(第1组)的信号平均心电图(ECG)的快速傅立叶变换(FFT),并将其与两个周期长度期间单次和双次额外刺激的程控心室刺激结果以及两个右心室部位的快速起搏进行了比较。FFT数据表示为面积比,该面积比量化了终末QRS和ST段中20至50 Hz频率的相对贡献。使用以诱导因子作为因变量的逻辑回归来帮助将大于20的面积比值定义为异常。在18名患者中诱导了持续性单形性VT,每名患者的面积比值均大于20。两名患者未诱发持续性室性心动过速,每名患者的面积比值均小于20。FFT数据,然后进行了前瞻性比较,在38例(第二组)与非持续性VT(12例)或晕厥(26例)的电生理研究的程控刺激的结果。组II中FFT值正常的26例患者均未诱发VT。在12例FFT值异常的患者中,有5例诱导了持续性单形性VT。因此,FFT分析的结果正确预测了88%的研究患者和82%的II组晕厥或非持续性VT患者的程控心室刺激结果。此外,II组中诱导持续性VT的所有5例患者均被正确识别。(250字处删节)
Improved selection of patients with suspected sustained ventricular tachycardia (VT) for programmed ventricular stimulation is needed. To determine if frequency analysis detects patients in whom sustained VT might be induced, we first obtained fast-Fourier transforms (FFT) of signal-averaged electrocardiograms (ECGs) from 20 patients with spontaneous sustained VT (group 1) and compared them with the results of programmed ventricular stimulation with single and double extrastimuli during two cycle lengths and burst pacing from two right ventricular sites. The FFT data were expressed as an area ratio that quantified the relative contributions of 20 to 50 Hz frequencies in the terminal QRS and ST segment. A logistic regression with inducibility as the dependent variable was used to help define area ratio values greater than 20 as abnormal. Sustained monomorphic VT was induced in 18 patients, each with an area ratio value greater than 20. Sustained VT was not induced in two patients, each with an area ratio value less than 20. FFT data were then compared prospectively with the results of programmed stimulation in 38 patients (group II) with nonsustained VT (12 patients) or syncope (26 patients) referred for electrophysiologic study. In none of the 26 patients in group II with normal FFT values was VT inducible. Sustained monomorphic VT was induced in five of 12 patients with abnormal FFT values. Thus, the results of FFT analysis correctly predicted the results of programmed ventricular stimulation in 88% of patients studied and in 82% of patients in group II with syncope or nonsustained VT. Moreover, all five patients in group II in whom sustained VT was induced were identified correctly.(ABSTRACT TRUNCATED AT 250 WORDS)
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