A History Of Depression With Psychotic Features Modifies A Woman's Risk For Depression After Childbirth.

A History Of Depression With Psychotic Features Modifies A Woman's Risk For Depression After Childbirth.
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具有精神病性特征的抑郁史会改变女性产后抑郁的风险。

DOI:
10.1080/17522439.2020.1720274
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发表时间:
2020
期刊:
影响因子:
1.2
通讯作者:
Sandin S
Sandin S
中科院分区:
医学4区
文献类型:
--
作者:
Silverman ME;Goldstein MA;Smith L;Reichenberg A;Lichtenstein P;Sandin S

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目的产后抑郁症(PPD)是一种普遍存在的疾病,可能导致儿童发育不良。虽然单相抑郁症的母亲病史被认为是最大的危险因素,但具有精神病特征的单相抑郁病史如何改变 PPD 风险仍不清楚。方法在 1997 年至 2008 年瑞典所有单胎出生妇女的前瞻性队列中,该研究探讨了有抑郁病史的母亲(无论有无精神病特征)发生 PPD 的相对风险 (RR)。结果在观察的 707,701 名母亲中,有 4,397 名母亲接受了 PPD 治疗。 PPD 诊断(每 10,000 人中有 62 人)。无抑郁病史的女性 PPD 发病率为每 10,000 人 48 人,而有抑郁病史的女性为每 10,000 人 1,154 人 (RR = 27.0)。有抑郁病史(包括精神病特征)的女性中,产后抑郁症(PPD)的发病率为每 10,000 人 2,360 例(RR = 37.9)。 结论 与有抑郁病史但无精神病特征的女性相比,有精神病史的抑郁症女性的 PPD 风险显着升高。
ObjectivePostpartum depression (PPD) is a prevalent disorder that can result in negative child developmental outcomes. While a maternal history of unipolar depression is understood to be the largest risk factor, how a history of unipolar depression with psychotic features modifies PPD risk remains unclear.MethodsIn a prospective cohort of all women with single infant births in Sweden, 1997–2008, the study explored the relative risk (RR) of PPD for mothers with a depression history, both with and without psychotic features.ResultsOf the 707,701 mothers observed, 4,397 received a PPD diagnosis (62 per 10,000). PPD incidence in women without a depression history was 48 per 10,000 compared to 1,154 per 10,000 for those with a depression history (RR = 27.0). The incidence of PPD in women with a depression history that included psychotic features was 2,360 per 10,000 (RR = 37.9).ConclusionPPD risk is significantly elevated among women who had a history of depression with psychotic features compared to women with a history of depression without psychotic features.
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