Risk factors for and perinatal outcomes of major depression during pregnancy: a population-based analysis during 2002-2010 in Finland.
Risk factors for and perinatal outcomes of major depression during pregnancy: a population-based analysis during 2002-2010 in Finland.
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DOI：
10.1136/bmjopen-2014-004883
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发表时间：
2014-11-14
期刊：
影响因子：
2.9
通讯作者：
Heinonen S
中科院分区：
文献类型：
--
作者：
Räisänen S;Lehto SM;Nielsen HS;Gissler M;Kramer MR;Heinonen S
确定妊娠期间医生诊断的重度抑郁症在专门医疗保健机构接受治疗的危险因素和后果（几种不良的围产期结局）。基于人群的横断面研究。数据收集自 1996 年至 2010 年芬兰健康登记册。 2002 年至 2010 年芬兰的所有单胎出生 (n=511 938)。怀孕期间重度抑郁症的患病率、危险因素和后果。在511 938名女性中，0.8%的人在怀孕期间经历过重度抑郁症，其中46.9%的人在怀孕前有抑郁症病史。除抑郁史外，重度抑郁症的第二大相关因素是对分娩的恐惧，其患病率增加了 2.6 倍（调整后 OR（aOR=2.63，95% CI 2.39 至 2.89））。重度抑郁症的风险状况还包括青少年或高龄产妇、低或未明确的社会经济地位 (SES)、单身婚姻状况、吸烟、既往妊娠终止、贫血和妊娠糖尿病，无论是否有抑郁病史。患有重度抑郁症的妇女的妊娠率比没有患重度抑郁症的妇女要差。吸烟对小于胎龄新生儿（低于平均出生体重<−2 SD）、低出生体重（<2500 g）、早产（<37 周）和入院与重度抑郁症相关的新生儿重症监护的影响较大，而妊娠期间医生诊断的重度抑郁症的影响很小。最强的危险因素是病史。其他相关因素包括对分娩的恐惧、社会经济地位低、缺乏社会支持以及吸烟等不健康的生殖行为，怀孕期间吸烟对妊娠期间抑郁症的不良后果有显着或中等程度的影响。
To identify risk factors for and the consequences (several adverse perinatal outcomes) of physician-diagnosed major depression during pregnancy treated in specialised healthcare. A population-based cross-sectional study. Data were gathered from Finnish health registers for 1996–2010. All singleton births (n=511 938) for 2002–2010 in Finland. Prevalence, risk factors and consequences of major depression during pregnancy. Among 511 938 women, 0.8% experienced major depression during pregnancy, of which 46.9% had a history of depression prior to pregnancy. After history of depression, the second strongest associated factor for major depression was fear of childbirth, with a 2.6-fold (adjusted OR (aOR=2.63, 95% CI 2.39 to 2.89) increased prevalence. The risk profile of major depression also included adolescent or advanced maternal age, low or unspecified socioeconomic status (SES), single marital status, smoking, prior pregnancy terminations, anaemia and gestational diabetes regardless of a history of depression. Outcomes of pregnancies were worse among women with major depression than without. The contribution of smoking was substantial to modest for small-for-gestational age newborn (<−2 SD below mean birth), low birth weight (<2500 g), preterm birth (<37 weeks) and admission to neonatal intensive care associated with major depression, whereas SES made only a minor contribution. Physician-diagnosed major depression during pregnancy was found to be rare. The strongest risk factor was history of depression prior to pregnancy. Other associated factors were fear of childbirth, low SES, lack of social support and unhealthy reproductive behaviour such as smoking. Outcomes of pregnancies were worse among women with major depression than without. Smoking during pregnancy made a substantial to modest contribution to adverse outcomes associated with depression during pregnancy.
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DOI：
10.1111/1471-0528.12599
发表时间：
2014-07-01
影响因子：
5.8
作者：
Raisanen, S.;Lehto, S. M.;Heinonen, S.
通讯作者：
Heinonen, S.
影响因子：
3.1
作者：
Howard, Louise M.;Flach, Clare;Tylee, Andre
通讯作者：
Tylee, Andre
影响因子：
3.4
作者：
Mortensen, Laust H.;Lauridsen, Jorgen T.;Andersen, Anne-Marie N.
通讯作者：
Andersen, Anne-Marie N.
影响因子：
4.4
作者：
Sankilampi, Ulla;Hannila, Marja-Leena;Dunkel, Leo
通讯作者：
Dunkel, Leo
影响因子：
6.3
作者：
Gissler, M.;Rahkonen, O.;Hemminki, E.
通讯作者：
Hemminki, E.