Cytokine Networks between Innate Lymphoid Cells and Myeloid Cells.
Cytokine Networks between Innate Lymphoid Cells and Myeloid Cells.
复制标题
DOI：
10.3389/fimmu.2018.00191
复制
发表时间：
2018
影响因子：
7.3
通讯作者：
Burrows K
中科院分区：
文献类型：
--
作者：
Mortha A;Burrows K
先天性淋巴样细胞（ILC）是脊椎动物先天免疫系统的重要组成部分。它们在发育上植根于淋巴谱系，并且可以分化成至少三种转录上不同的谱系。ILC接种淋巴和非淋巴组织，并在组织驻留池中局部自我维持。组织驻留ILC执行重要的效应器功能，使其成为组织稳态、修复、重塑、微生物防御和抗肿瘤免疫的关键调节剂。与T淋巴细胞类似，ILC仅具有很少的用于识别非自身的感觉元件，因此依赖于驻留在组织内的外部细胞感觉元件。髓样细胞，包括单核吞噬细胞（MNP），是组织的关键哨兵，能够将环境线索转化为指示淋巴细胞反应的效应物。因此，骨髓细胞对组织状态的适应影响ILC的效应程序，并作为环境信号如何通过组织驻留免疫细胞交叉作用整合到ILC功能中的示例。本文综述了髓系细胞在调节ILC功能中的作用，并讨论了ILC和髓系细胞之间的反馈通信如何有助于稳定免疫稳态，以维持器官的健康状态。
Innate lymphoid cells (ILCs) are an essential component of the innate immune system in vertebrates. They are developmentally rooted in the lymphoid lineage and can diverge into at least three transcriptionally distinct lineages. ILCs seed both lymphoid and non-lymphoid tissues and are locally self-maintained in tissue-resident pools. Tissue-resident ILCs execute important effector functions making them key regulator in tissue homeostasis, repair, remodeling, microbial defense, and anti-tumor immunity. Similar to T lymphocytes, ILCs possess only few sensory elements for the recognition of non-self and thus depend on extrinsic cellular sensory elements residing within the tissue. Myeloid cells, including mononuclear phagocytes (MNPs), are key sentinels of the tissue and are able to translate environmental cues into an effector profile that instructs lymphocyte responses. The adaptation of myeloid cells to the tissue state thus influences the effector program of ILCs and serves as an example of how environmental signals are integrated into the function of ILCs via a tissue-resident immune cell cross talks. This review summarizes our current knowledge on the role of myeloid cells in regulating ILC functions and discusses how feedback communication between ILCs and myeloid cells contribute to stabilize immune homeostasis in order to maintain the healthy state of an organ.
登录
查看更多内容
影响因子：
64.8
作者：
Cella, Marina;Fuchs, Anja;Vermi, William;Facchetti, Fabio;Otero, Karel;Lennerz, Jochen K. M.;Doherty, Jason M.;Mills, Jason C.;Colonna, Marco
通讯作者：
Colonna, Marco
影响因子：
82.9
作者：
Crome SQ;Nguyen LT;Lopez-Verges S;Yang SY;Martin B;Yam JY;Johnson DJ;Nie J;Pniak M;Yen PH;Milea A;Sowamber R;Katz SR;Bernardini MQ;Clarke BA;Shaw PA;Lang PA;Berman HK;Pugh TJ;Lanier LL;Ohashi PS
通讯作者：
Ohashi PS
影响因子：
32.4
作者：
Bernink, Jochem H.;Krabbendam, Lisette;Spits, Hergen
通讯作者：
Spits, Hergen
影响因子：
30.5
作者：
Bernink, Jochem H.;Peters, Charlotte P.;Spits, Hergen
通讯作者：
Spits, Hergen
DOI：
10.1084/jem.20111453
发表时间：
2012-08-27
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Coccia M;Harrison OJ;Schiering C;Asquith MJ;Becher B;Powrie F;Maloy KJ
通讯作者：
Maloy KJ