The lifecycle of the Ebola virus in host cells.
The lifecycle of the Ebola virus in host cells.
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DOI：
10.18632/oncotarget.18498
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发表时间：
2017-08-15
期刊：
影响因子：
--
通讯作者：
Yao HP
中科院分区：
文献类型：
--
作者：
Yu DS;Weng TH;Wu XX;Wang FXC;Lu XY;Wu HB;Wu NP;Li LJ;Yao HP
由于感染丝状病毒科的埃博拉病毒(EBOV)属，埃博拉出血热在人类和非人类灵长类动物中导致致命疾病。然而，EBOV在宿主细胞中的生命周期机制，包括病毒进入、膜融合、RNP形成、GP-tetherin相互作用以及VP40-内小叶结合等机制仍不清楚。本文综述了EBOV蛋白的生物学功能及其在生命周期中的作用，总结了EBOV蛋白或RNA在不同阶段表达的相关因素，并综述了EBOV生命周期的分子事件和机制的研究进展。此外，综述还概述了在未来的研究中迫切需要解决的方面。
Ebola haemorrhagic fever causes deadly disease in humans and non-human primates resulting from infection with the Ebola virus (EBOV) genus of the family Filoviridae. However, the mechanisms of EBOV lifecycle in host cells, including viral entry, membrane fusion, RNP formation, GP-tetherin interaction, and VP40-inner leaflet association remain poorly understood. This review describes the biological functions of EBOV proteins and their roles in the lifecycle, summarizes the factors related to EBOV proteins or RNA expression throughout the different phases, and reviews advances with regards to the molecular events and mechanisms of the EBOV lifecycle. Furthermore, the review outlines the aspects remain unclear that urgently need to be solved in future research.
影响因子：
5.8
作者：
Prehn RT
通讯作者：
Prehn RT