Optimizing background suppression for dual-module velocity-selective arterial spin labeling: Without using additional background-suppression pulses.
Optimizing background suppression for dual-module velocity-selective arterial spin labeling: Without using additional background-suppression pulses.
复制标题
优化双模块速度选择性动脉自旋标记的背景抑制：不使用额外的背景抑制脉冲。
DOI：
10.1002/mrm.29995
复制
发表时间：
2024
影响因子：
3.3
通讯作者：
Guo,Jia
中科院分区：
文献类型：
--
作者：
Guo,Jia
目的：背景抑制（BS）被推荐用于动脉自旋标记（ASL）以提高信噪比，但在现有的速度选择性ASL （VSASL）方法中难以优化。双模块VSASL （dm - VSASL）能够实现延迟不敏感、鲁棒性和信噪比高效的灌注成像，同时实现高效的BS，但其优化尚未得到彻底的研究。方法利用速度选择标记脉冲的反演效应，如速度选择反演（VSI），可用于BS，并在dm - VSASL中进行建模以优化BS。采用双模VSI （dm - VSI）进行体内实验，比较两种BS策略：一种是常规的附加BS脉冲策略，另一种是不含BS脉冲的新策略。以脉冲和伪连续ASL （PASL和PCASL）作为参考，对它们的BS性能、时间噪声和时间信噪比进行了测试和比较。结果体内实验验证了BS模型的有效性。在PASL/PCASL和dm - VSI中，时间噪声与组织信号之间存在强的正线性相关（r> 0.82,p< 0.0001）。在dm - VSI中，无论是否有额外的BS脉冲，都可以实现最佳BS；后者对ASL信号的改善程度分别为灰质的8.5% （p= 0.006）和白质的12.2% (p= 0.014)，并倾向于提供更好的时间信噪比。dm - VSI测量的ASL信号（p< 0.016）和时间信噪比（p< 0.018）明显高于PASL和PCASL。侵袭性BS需要复杂的重建。结论在建模的指导下，dm - VSASL在没有BS脉冲的情况下可以实现最佳BS，进一步改善了ASL信号和信噪比性能。
PurposeBackground suppression (BS) is recommended in arterial spin labeling (ASL) for improved SNR but is difficult to optimize in existing velocity‐selective ASL (VSASL) methods. Dual‐module VSASL (dm‐VSASL) enables delay‐insensitive, robust, and SNR‐efficient perfusion imaging, while allowing efficient BS, but its optimization has yet to be thoroughly investigated.MethodsThe inversion effects of the velocity‐selective labeling pulses, such as velocity‐selective inversion (VSI), can be used for BS, and were modeled for optimizing BS in dm‐VSASL. In vivo experiments using dual‐module VSI (dm‐VSI) were performed to compare two BS strategies: a conventional one with additional BS pulses and a new one without any BS pulse. Their BS performance, temporal noise, and temporal SNR were examined and compared, with pulsed and pseudo‐continuous ASL (PASL and PCASL) as the reference.ResultsThe in vivo experiments validated the BS modeling. Strong positive linear correlations (r> 0.82,p< 0.0001) between the temporal noise and the tissue signal were found in PASL/PCASL and dm‐VSI. Optimal BS can be achieved with and without additional BS pulses in dm‐VSI; the latter improved the ASL signals by 8.5% in gray matter (p= 0.006) and 12.2% in white matter (p= 0.014) and tended to provide better temporal SNR. The dm‐VSI measured significantly higher ASL signal (p< 0.016) and temporal SNR (p< 0.018) than PASL and PCASL. Complex reconstruction was found necessary with aggressive BS.ConclusionGuided by modeling, optimal BS can be achieved without any BS pulse in dm‐VSASL, further improving the ASL signal and the SNR performance.
影响因子：
3.3
作者：
Hernandez-Garcia, Luis;Aramendia-Vidaurreta, Veronica;Bolar, Divya S.;Dai, Weiying;Fernandez-Seara, Maria A.;Guo, Jia;Madhuranthakam, Ananth J.;Mutsaerts, Henk;Petr, Jan;Qin, Qin;Schollenberger, Jonas;Suzuki, Yuriko;Taso, Manuel;Thomas, David L.;van Osch, Matthias J. P.;Woods, Joseph;Yan, Lirong;Wang, Ze;Zhao, Li;Zhao, Moss Y.;Okell, Thomas W.
通讯作者：
Okell, Thomas W.
影响因子：
3.3
作者：
Alsop, David C.;Detre, John A.;Golay, Xavier;Guenther, Matthias;Hendrikse, Jeroen;Hernandez-Garcia, Luis;Lu, Hanzhang;MacIntosh, Bradley J.;Parkes, Laura M.;Smits, Marion;van Osch, Matthias J. P.;Wang, Danny J. J.;Wong, Eric C.;Zaharchuk, Greg
通讯作者：
Zaharchuk, Greg