Severe Acute Respiratory Syndrome (SARS) and the GDP. Part I : Epidemiology, virology, pathology and general health issues.
Severe Acute Respiratory Syndrome (SARS) and the GDP. Part I : Epidemiology, virology, pathology and general health issues.
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严重的急性呼吸综合征（SARS）和GDP。第一部分：流行病学，病毒学，病理学和一般健康问题。
DOI：
10.1038/sj.bdj.4811469
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发表时间：
2004-07-24
影响因子：
2.6
通讯作者：
Samaranayake LP
中科院分区：
文献类型：
--
作者：
Li RW;Leung KW;Sun FC;Samaranayake LP
SARS是一种传染性极强、进展迅速的非典型肺炎，由一种新发现的冠状病毒（SARS-CoV）引起。诊断是基于临床表现，流行病学和排除其他肺炎，并通过阳性血清转换确认。目前还没有确定的治疗方案。症状可能与其他传染性较低或病态疾病相似，超过四分之一的受影响者是毫无戒心的医护人员。医护人员必须熟悉严重急性呼吸系统综合症的临床特征和个案定义，以协助甄别疾病和防止传播。建议对可能的SARS进行监测，控制流行病取决于早期识别和隔离带菌者以及有效的感染控制和公共卫生措施。随着一种新型病毒性疾病严重急性呼吸系统综合征（SARS）的出现，卫生专业面临着一个新的挑战。SARS是由一种名为SARS-CoV的冠状病毒引起的一种非典型肺炎。这种传染性极强的疾病已蔓延到32个国家，在短短6个多月内感染了8 400多名患者，造成790多人死亡。超过四分之一的感染者是毫无戒心的医护人员。SARS冠状病毒的主要传播方式似乎是通过飞沫传播，还有其他次要的传播方式，如密切接触和污染物，尽管空气传播尚未排除。目前还没有确定的治疗方案。虽然爆发的高峰期可能已经过去，因此英国的SARS风险被评估为很低，但世界卫生组织已要求所有国家保持警惕，以免SARS再次出现。最近从中国台湾和北京报告的实验室获得的SARS病例证明了这种风险。在可靠的诊断测试、疫苗和药物可用之前，控制SARS爆发取决于密切监测、及早识别指示病例、迅速隔离带菌者以及有效的感染控制和公共卫生措施。
SARS is a highly infectious and rapidly progressive form of atypical pneumonia caused by a newly identified strain of coronavirus (SARS-CoV). Diagnosis is based on clinical findings, epidemiology and exclusion from other pneumonias and is confirmed by a positive seroconversion. There is as yet no definitive treatment protocol. Symptoms may be similar to other less infective or morbid diseases and over one quarter of those affected have been unsuspecting healthcare workers. HCW must be familiar with the clinical features and case definitions of SARS to assist in the screening of the disease and prevention of spread. Surveillance for possible SARS is recommended and control of the epidemic depends on early identification and isolation of carriers and effective infection control and public health measures. The health profession faces a new challenge with the emergence of a novel viral disease Severe Acute Respiratory Syndrome (SARS), a form of atypical pneumonia caused by a coronavirus termed SARS-CoV. This highly infectious disease has spread through 32 countries, infecting more than 8,400 patients with over 790 deaths in just over 6 months. Over one quarter of those infected were unsuspecting healthcare workers. The major transmission mode of SARS-coronavirus appears to be through droplet spread with other minor subsidiary modes of transmission such as close contact and fomites although air borne transmission has not been ruled out. There is as yet no definitive treatment protocol. Although the peak period of the outbreak is likely to have passed and the risk of SARS in the UK is therefore assessed to be low, the World Health Organisation has asked all countries to remain vigilant lest SARS re-emerges. Recent laboratory acquired cases of SARS reported from Taiwan and Beijing, China are a testimony to this risk. Until reliable diagnostic tests, vaccine and medications are available, control of SARS outbreaks depends on close surveillance, early identification of index cases, quick isolation of carriers and effective infection control and public health measures.
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DOI：
10.1016/s0140-6736(03)13077-2
发表时间：
2003-04-19
期刊：
Lancet (London, England)
影响因子：
--
作者：
Peiris JS;Lai ST;Poon LL;Guan Y;Yam LY;Lim W;Nicholls J;Yee WK;Yan WW;Cheung MT;Cheng VC;Chan KH;Tsang DN;Yung RW;Ng TK;Yuen KY;SARS study group
通讯作者：
SARS study group
影响因子：
1.8
作者：
GHOSE, TK
通讯作者：
GHOSE, TK
影响因子：
158.5
作者：
Poutanen, SM;Low, DE;McGeer, AJ
通讯作者：
McGeer, AJ
影响因子：
158.5
作者：
Ksiazek, TG;Erdman, D;Anderson, LJ
通讯作者：
Anderson, LJ
影响因子：
56.9
作者：
Rota, PA;Oberste, MS;Bellini, WJ
通讯作者：
Bellini, WJ