Targeting Macrophage Migration Inhibitory Factor in Acute Pancreatitis and Pancreatic Cancer.
Targeting Macrophage Migration Inhibitory Factor in Acute Pancreatitis and Pancreatic Cancer.
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靶向急性胰腺炎和胰腺癌中的巨噬细胞迁移抑制因子
DOI：
10.3389/fphar.2021.638950
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发表时间：
2021
影响因子：
5.6
通讯作者：
Huang W
中科院分区：
文献类型：
--
作者：
Wen Y;Cai W;Yang J;Fu X;Putha L;Xia Q;Windsor JA;Phillips AR;Tyndall JDA;Du D;Liu T;Huang W
巨噬细胞移动抑制因子（MIF）是一种多效性细胞因子，参与炎症和癌症的发病机制。它由各种细胞产生，循环MIF已被确定为一系列疾病的生物标志物。细胞外MIF主要与分化抗原74（CD 74）/CD 44结合，激活下游信号通路。这些反过来激活免疫反应，增强炎症，并可促进癌细胞增殖和侵袭。细胞外MIF还与C-X-C趋化因子受体结合，与或不与CD 74合作以激活趋化因子反应。细胞内MIF参与Toll样受体和炎性小体介导的炎症反应。MIF的药理学抑制已经显示在治疗炎性疾病和癌症中具有很大的前景，包括靶向MIF的互变异构酶活性位点的小分子MIF抑制剂和中和MIF的抗体。本文就MIF信号通路在炎症和肿瘤中的作用进行综述，并对MIF在胰腺外分泌疾病的实验和临床研究进展进行综述。我们希望提供深入了解临床翻译的MIF拮抗作用作为一种策略，治疗急性胰腺炎和胰腺癌。
Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine implicated in the pathogenesis of inflammation and cancer. It is produced by various cells and circulating MIF has been identified as a biomarker for a range of diseases. Extracellular MIF mainly binds to the cluster of differentiation 74 (CD74)/CD44 to activate downstream signaling pathways. These in turn activate immune responses, enhance inflammation and can promote cancer cell proliferation and invasion. Extracellular MIF also binds to the C-X-C chemokine receptors cooperating with or without CD74 to activate chemokine response. Intracellular MIF is involved in Toll-like receptor and inflammasome-mediated inflammatory response. Pharmacological inhibition of MIF has been shown to hold great promise in treating inflammatory diseases and cancer, including small molecule MIF inhibitors targeting the tautomerase active site of MIF and antibodies that neutralize MIF. In the current review, we discuss the role of MIF signaling pathways in inflammation and cancer and summarize the recent advances of the role of MIF in experimental and clinical exocrine pancreatic diseases. We expect to provide insights into clinical translation of MIF antagonism as a strategy for treating acute pancreatitis and pancreatic cancer.
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DOI：
10.4049/jimmunol.181.4.2330
发表时间：
2008-08-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Coleman AM;Rendon BE;Zhao M;Qian MW;Bucala R;Xin D;Mitchell RA
通讯作者：
Mitchell RA
影响因子：
82.9
作者：
Calandra, T;Echtenacher, B;Glauser, MP
通讯作者：
Glauser, MP
影响因子：
21.3
作者：
Costa-Silva B;Aiello NM;Ocean AJ;Singh S;Zhang H;Thakur BK;Becker A;Hoshino A;Mark MT;Molina H;Xiang J;Zhang T;Theilen TM;García-Santos G;Williams C;Ararso Y;Huang Y;Rodrigues G;Shen TL;Labori KJ;Lothe IM;Kure EH;Hernandez J;Doussot A;Ebbesen SH;Grandgenett PM;Hollingsworth MA;Jain M;Mallya K;Batra SK;Jarnagin WR;Schwartz RE;Matei I;Peinado H;Stanger BZ;Bromberg J;Lyden D
通讯作者：
Lyden D
影响因子：
5
作者：
Baugh, JA;Chitnis, S;Bucala, R
通讯作者：
Bucala, R
DOI：
10.1073/pnas.56.1.72
发表时间：
1966-01-01
影响因子：
11.1
作者：
DAVID, JR
通讯作者：
DAVID, JR