Spontaneous, persistent infection of a B‐cell lymphoma with adenovirus
Spontaneous, persistent infection of a B‐cell lymphoma with adenovirus
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B 细胞淋巴瘤腺病毒自发、持续感染
DOI：
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发表时间：
1996
影响因子：
12.7
通讯作者：
J. Casper
中科院分区：
文献类型：
--
作者：
P. Flomenberg;V. Piaskowski;J. Harb;A. Segura;J. Casper
An adenovirus culture‐positive lymphoblastoid cell line was derived from a bone marrow transplant recipient with fatal B‐cell lymphoproliferative disease and adenovirus pneumonia. At autopsy, focal areas of the lymphoma infiltrating the patient's lung were positive for adenovirus proteins by immunohistochemical staining. The Epstein‐Barr virus‐transformed B‐cell line Mk, established from pleural fluid cells, contained adenovirus virions in both the nucleus and the cytoplasm by electron microscopy. The majority of Mk cells expressed adenovirus proteins and produced a high level of infectious adenovirus by plaque assay analysis. However, in contrast to the rapid cell death induced by adenovirus in other permissive cell lines, Mk was maintained stably in tissue culture for 6 months. These data indicate that adenoviral replication is not sufficient for cell lysis and confirm that adenovirus can cause persistent infection in human lymphoid cells in vivo. © 1996 Wiley‐Liss, Inc.
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影响因子：
4.4
作者：
W. Storkus;D. Howell;R. Salter;J. Dawson;P. Cresswell
通讯作者：
W. Storkus;D. Howell;R. Salter;J. Dawson;P. Cresswell
影响因子：
3.7
作者：
OMALLEY, RP;DUNCAN, RF;MATHEWS, MB
通讯作者：
MATHEWS, MB
骨髓移植后 Epstein-Barr 病毒相关的 B 细胞淋巴增殖性疾病。
影响因子：
20.3
作者：
Shapiro,RS;McClain,K;Frizzera,G;Gajl-Peczalska,KJ;Kersey,JH;Blazar,BR;Arthur,DC;Patton,DF;Greenberg,JS;Burke,B
通讯作者：
Burke,B
影响因子：
3.7
作者：
SILVER, L;ANDERSON, CW
通讯作者：
ANDERSON, CW