Impossibility of Consistent Distance Estimation from Sequence Lengths Under the TKF91 Model
Impossibility of Consistent Distance Estimation from Sequence Lengths Under the TKF91 Model
复制标题
TKF91模型下不可能根据序列长度进行一致的距离估计
DOI:
10.1007/s11538-020-00801-3
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发表时间:
2020
影响因子:
3.5
通讯作者:
Roch, Sebastien
中科院分区:
文献类型:
--
作者:
Fan, Wai-Tong Louis;Legried, Brandon;Roch, Sebastien
We consider the problem of distance estimation under the TKF91 model of sequence evolution by insertions, deletions and substitutions on a phylogeny. In an asymptotic regime where the expected sequence lengths tend to infinity, we show that no consistent distance estimation is possible from sequence lengths alone. More formally, we establish that the distributions of pairs of sequence lengths at different distances cannot be distinguished with probability going to one.
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通讯作者:
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