Locally sourced: site-specific immune barriers to metastasis.
Locally sourced: site-specific immune barriers to metastasis.
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DOI：
10.1038/s41577-023-00836-2
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发表时间：
2023-08
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肿瘤细胞很早就从原发部位迁移到远处，但转移通常需要数年时间才能在临床上表现出来，甚至在患者一生中从未出现。这种癌症进展的停顿强调了限制远处播散性肿瘤细胞（DTC）生长的障碍的存在。虽然这些转移障碍的性质可能包括DTC的内在特征，但最近的研究已经确定，局部微环境也控制着转移的形成。在这个角度来看，我讨论了免疫系统的位点特异性差异如何可能是DTC的主要选择性生长抑制，并认为利用组织免疫将是免疫治疗发展的下一阶段必不可少的，这可靠地防止了转移的建立。一个播散的肿瘤细胞只有在到达一个“肥沃”的远端部位时才会生长，正如Ana Luísa Correia所假设的那样，这在很大程度上取决于该部位的免疫环境。局部免疫细胞类型、比率和空间位置的位点特异性差异影响播散性肿瘤细胞是否建立转移或保持休眠。
Tumour cells migrate very early from primary sites to distant sites, and yet metastases often take years to manifest themselves clinically or never even surface within a patient’s lifetime. This pause in cancer progression emphasizes the existence of barriers that constrain the growth of disseminated tumour cells (DTCs) at distant sites. Although the nature of these barriers to metastasis might include DTC-intrinsic traits, recent studies have established that the local microenvironment also controls the formation of metastases. In this Perspective, I discuss how site-specific differences of the immune system might be a major selective growth restraint on DTCs, and argue that harnessing tissue immunity will be essential for the next stage in immunotherapy development that reliably prevents the establishment of metastases. A disseminated tumour cell will grow only if it arrives at a ‘fertile’ distant site, which as Ana Luísa Correia posits is determined largely by the immune context at the site. Site-specific differences in local immune cell types, ratios and spatial locations influence whether a disseminated tumour cell establishes metastases or is kept dormant.
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影响因子：
20.8
作者：
Bondareva, Olga;Rodriguez-Aguilera, Jesus Rafael;Oliveira, Fabiana;Liao, Longsheng;Rose, Alina;Gupta, Anubhuti;Singh, Kunal;Geier, Florian;Schuster, Jenny;Boeckel, Jes-Niels;Buescher, Joerg M.;Kohli, Shrey;Kloeting, Nora;Isermann, Berend;Blueher, Matthias;Sheikh, Bilal N.
通讯作者：
Sheikh, Bilal N.
影响因子：
32.4
作者：
Aegerter, Helena;Lambrecht, Bart N.;Jakubzick, Claudia, V
通讯作者：
Jakubzick, Claudia, V
影响因子：
--
作者：
Budczies J;von Winterfeld M;Klauschen F;Bockmayr M;Lennerz JK;Denkert C;Wolf T;Warth A;Dietel M;Anagnostopoulos I;Weichert W;Wittschieber D;Stenzinger A
通讯作者：
Stenzinger A
DOI：
10.1126/science.aao4227
发表时间：
2018-09-28
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Albrengues J;Shields MA;Ng D;Park CG;Ambrico A;Poindexter ME;Upadhyay P;Uyeminami DL;Pommier A;Küttner V;Bružas E;Maiorino L;Bautista C;Carmona EM;Gimotty PA;Fearon DT;Chang K;Lyons SK;Pinkerton KE;Trotman LC;Goldberg MS;Yeh JT;Egeblad M
通讯作者：
Egeblad M
DOI：
10.1038/s41577-019-0131-x
发表时间：
2019-04
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
Altan-Bonnet G;Mukherjee R
通讯作者：
Mukherjee R