Evolution of Deep Brain Stimulation: Human Electrometer and Smart Devices Supporting the Next Generation of Therapy.
Evolution of Deep Brain Stimulation: Human Electrometer and Smart Devices Supporting the Next Generation of Therapy.
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DOI：
10.1111/j.1525-1403.2009.00199.x
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发表时间：
2009-04
期刊：
影响因子：
--
通讯作者：
Cho ZH
中科院分区：
文献类型：
--
作者：
Lee KH;Blaha CD;Garris PA;Mohseni P;Horne AE;Bennet KE;Agnesi F;Bledsoe JM;Lester DB;Kimble C;Min HK;Kim YB;Cho ZH
脑深部电刺激（DBS）为多种神经病理提供治疗益处，包括帕金森病（PD）、癫痫、慢性疼痛和抑郁症。尽管DBS的临床疗效已得到充分证实，但其机制仍知之甚少。在这篇综述中，我们开始总结目前的理解DBS机制。使用这些知识作为一个框架，然后，我们探讨了一个具体的假设，DBS的丘脑底核（DBS）治疗PD。这一假说指出，治疗益处至少部分是通过激活存活的黑质纹状体多巴胺能神经元、随后的纹状体多巴胺释放和多巴胺恢复纹状体靶细胞控制来提供的。虽然极具争议，我们目前的初步数据是一致的具体预测测试这一假设。我们还建议开发新技术，例如，人体静电计和闭环智能设备，用于监测脑深部电刺激期间多巴胺能神经传递，将进一步推进这种治疗方法。
Deep Brain Stimulation (DBS) provides therapeutic benefit for several neuropathologies including Parkinson’s disease (PD), epilepsy, chronic pain, and depression. Despite well established clinical efficacy, the mechanism(s) of DBS remains poorly understood. In this review we begin by summarizing the current understanding of the DBS mechanism. Using this knowledge as a framework, we then explore a specific hypothesis regarding DBS of the subthalamic nucleus (STN) for the treatment of PD. This hypothesis states that therapeutic benefit is provided, at least in part, by activation of surviving nigrostriatal dopaminergic neurons, subsequent striatal dopamine release, and resumption of striatal target cell control by dopamine. While highly controversial, we present preliminary data that are consistent with specific predications testing this hypothesis. We additionally propose that developing new technologies, e.g., human electrometer and closed-loop smart devices, for monitoring dopaminergic neurotransmission during STN DBS will further advance this treatment approach.
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影响因子：
3
作者：
Borland, LM;Shi, GY;Michael, AC
通讯作者：
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作者：
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作者：
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