Preliminary findings of the effects of rivastigmine, an acetylcholinesterase inhibitor, on working memory in cocaine-dependent volunteers.
Preliminary findings of the effects of rivastigmine, an acetylcholinesterase inhibitor, on working memory in cocaine-dependent volunteers.
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DOI：
10.1016/j.pnpbp.2013.11.001
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发表时间：
2014-04-03
影响因子：
5.6
通讯作者：
De La Garza, Richard, II
中科院分区：
文献类型：
--
作者：
Mahoney, James J., III;Kalechstein, Ari D.;Verrico, Christopher D.;Arnoudse, Nicholas M.;Shapiro, Benjamin A.;De La Garza, Richard, II
Long-term cocaine use is a risk factor for the onset of neurocognitive impairment. This study sought to determine whether the cholinesterase inhibitor rivastigmine could improve neurocognitive performance in cocaine-dependent individuals. Cocaine-dependent individuals who were not seeking treatment at the time of enrollment in the study were randomly assigned to receive placebo (n = 16), rivastigmine 3 mg (n = 13), or rivastigmine 6 mg (n = 12). The baseline neurocognitive assessment, which included measures of attention/information processing (as measured by the Continuous Performance Task-II (CPT-II)), verbal learning/episodic memory (as measured by the Hopkins Verbal Learning Test-Revised (HVLT-R)), and working memory (as measured by the Dual N-Back Task), was conducted prior to the administration of study medication (Day 0). The follow-up assessment was conducted on Day 8 after the participants had received rivastigmine or placebo for 7 days (Day 2–8). Rivastigmine administration significantly improved performance on one measure of working memory span (mean n-back span). This study provides additional data showing that cocaine-associated neurocognitive impairment, specifically working memory deficits, can be remediated, at least to some degree.
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影响因子：
11
作者：
Feldman, Howard H.;Lane, Roger
通讯作者：
Lane, Roger
影响因子：
2.5
作者：
HURD, YL;WEISS, F;UNGERSTEDT, U
通讯作者：
UNGERSTEDT, U
影响因子：
4.7
作者：
Kalechstein, A. D.;Mahoney, J. J., III;De La Garza, R., II
通讯作者：
De La Garza, R., II
影响因子：
7.6
作者：
Adinoff, Bryon;Devous, Michael D., Sr.;Cullum, Munro
通讯作者：
Cullum, Munro
影响因子：
4.2
作者：
Aharonovich, E;Hasin, DS;Nunes, EV
通讯作者：
Nunes, EV