Working memory for vibrotactile frequencies: comparison of cortical activity in blind and sighted individuals.
Working memory for vibrotactile frequencies: comparison of cortical activity in blind and sighted individuals.
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DOI：
10.1002/hbm.20966
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发表时间：
2010-11
影响因子：
4.8
通讯作者：
Dixit, Sachin
中科院分区：
文献类型：
--
作者：
Burton, Harold;Sinclair, Robert J.;Dixit, Sachin
在盲人中，许多先前的功能神经成像研究显示，枕叶皮质对非视觉刺激表现出强烈的激活。这些激活所代表的认知过程并不完全确定，尽管已经证明了言语识别记忆的作用。在先天失明和有视力的受试者(每组10人)中，我们对比了延迟5s的振动触觉一回频率保持任务和振动触觉幅度改变(A-C)任务的反应；这两种任务都涉及相同的振动参数。一回范式需要不断更新工作记忆(WM)。两组的研究结果都证实了WM对右脑背外侧前额叶(DLPFC)和后顶叶皮质(PPC)的背侧/腹侧注意成分的作用。双侧腹外侧前额叶皮质的阴性结果表明任务表现没有发声。在双侧枕叶皮质，盲人对两种任务都表现出类似的积极反应，而西医在有视力的人中引起了较大的消极反应。研究表明，盲人对注意力资源的更大利用导致了背侧和腹侧注意系统、右DLPFC的更大反应，以及在躯体感觉和运动前皮质试验之间延迟的持续反应。在视力正常的患者中，躯体感觉和运动前区域的反应显示出与刺激试验间隔相匹配的重复峰值。盲人枕叶皮质的研究结果表明，触觉激活并不代表非言语工作记忆任务的认知操作。然而，这些数据表明，盲人的触觉信息在感觉加工中的作用与视觉刺激在视力患者枕叶皮质中的作用相似。
In blind, occipital cortex showed robust activation to non-visual stimuli in many prior functional neuroimaging studies. The cognitive processes represented by these activations are not fully determined, although a verbal recognition memory role has been demonstrated. In congenitally blind and sighted (10 per group) we contrasted responses to a vibrotactile one-back frequency retention task with 5s delays and a vibrotactile amplitude-change (A–C) task; both tasks involved the same vibration parameters. The one-back paradigm required continuous updating for working memory (WM). Findings in both groups confirmed roles in WM for right hemisphere dorsolateral prefrontal (DLPFC) and dorsal/ventral attention components of posterior parietal cortex (PPC). Negative findings in bilateral ventrolateral prefrontal cortex suggested task performance without sub-vocalization. In bilateral occipital cortex, blind showed comparable positive responses to both tasks whereas WM evoked large negative responses in sighted. Greater utilization of attention resources in blind were suggested as causing larger responses in dorsal and ventral attention systems, right DLPFC, and persistent responses across delays between trials in somatosensory and premotor cortex. In sighted, responses in somatosensory and premotor areas showed iterated peaks matched to stimulation trial intervals. The findings in occipital cortex of blind suggest that tactile activations do not represent cognitive operations for non-verbal WM task. However, these data suggest a role in sensory processing for tactile information in blind that parallels a similar contribution for visual stimuli in occipital cortex of sighted.
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影响因子：
3.7
作者：
Burton, H;Abend, NS;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
4.8
作者：
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通讯作者：
McLaren, DG
影响因子：
4.8
作者：
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McLaren, Donald G.
影响因子：
25
作者：
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通讯作者：
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影响因子：
64.8
作者：
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通讯作者：
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