The divergent roles of autophagy in ischemia and preconditioning.
The divergent roles of autophagy in ischemia and preconditioning.
复制标题
自噬在缺血和预处理中的不同作用
DOI：
10.1038/aps.2014.151
复制
发表时间：
2015-04
影响因子：
8.2
通讯作者：
Qin ZH
中科院分区：
文献类型：
--
作者：
Sheng R;Qin ZH
Autophagy is an evolutionarily conserved and lysosome-dependent process for degrading and recycling cellular constituents. Autophagy is activated following an ischemic insult or preconditioning, but it may exert dual roles in cell death or survival during these two processes. Preconditioning or lethal ischemia may trigger autophagy via multiple signaling pathways involving endoplasmic reticulum (ER) stress, AMPK/TSC/mTOR, Beclin 1/BNIP3/SPK2, and FoxO/NF-κB transcription factors, etc. Autophagy then interacts with apoptotic and necrotic signaling pathways to regulate cell death. Autophagy may also maintain cell function by removing protein aggregates or damaged mitochondria. To date, the dual roles of autophagy in ischemia and preconditioning have not been fully clarified. The purpose of the present review is to summarize the recent progress in the mechanisms underlying autophagy activation during ischemia and preconditioning. A better understanding of the dual effects of autophagy in ischemia and preconditioning could help to develop new strategies for the preventive treatment of ischemia.
登录
查看更多内容
影响因子：
3.7
作者：
Huang C;Andres AM;Ratliff EP;Hernandez G;Lee P;Gottlieb RA
通讯作者：
Gottlieb RA
影响因子：
3.5
作者：
Fujita, Eriko;Kouroku, Yoriko;Momoi, Takashi
通讯作者：
Momoi, Takashi
影响因子：
3.3
作者：
Carloni, S.;Buonocore, G.;Balduini, W.
通讯作者：
Balduini, W.
影响因子：
25.7
作者：
Domart, Marie-Charlotte;Degli Esposti, Davide;Lemoine, Antoinette
通讯作者：
Lemoine, Antoinette
影响因子：
13.3
作者：
Gurusamy, Narasimman;Lekli, Istyan;Das, Dipak K.
通讯作者：
Das, Dipak K.