Vascular responses to long- and short-term exposure to fine particulate matter: MESA Air (Multi-Ethnic Study of Atherosclerosis and Air Pollution).
Vascular responses to long- and short-term exposure to fine particulate matter: MESA Air (Multi-Ethnic Study of Atherosclerosis and Air Pollution).
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DOI：
10.1016/j.jacc.2012.08.973
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发表时间：
2012-11-20
影响因子：
24
通讯作者：
Kaufman, Joel D.
中科院分区：
文献类型：
--
作者：
Krishnan, Ranjini M.;Adar, Sara D.;Szpiro, Adam A.;Jorgensen, Neal W.;Van Hee, Victor C.;Barr, R. Graham;O'Neill, Marie S.;Herrington, David M.;Polak, Joseph F.;Kaufman, Joel D.
关键词：
本研究在一个大型多城市队列中，使用超声评估了长期和短期空气污染物暴露与肱动脉血流介导的扩张（FMD）和基线动脉直径（BAD）的相关性。暴露于环境空气污染，特别是长期暴露于空气动力学直径<2.5 μm的颗粒物（PM2.5），与心血管死亡率有关。短期暴露于PM2.5与FMD降低和血管收缩相关，表明PM2.5的不良影响可能涉及内皮功能障碍。然而，尚未研究PM2.5对内皮功能障碍的长期影响。在多种族动脉粥样硬化研究的初始检查中，通过肱动脉超声测量FMD和BAD。长期的PM2.5浓度估计为2000年在每个参与者的住所（n = 3,040）使用的时空模型通知队列特定的监测。短期PM2.5浓度基于6个城市的每日中心站点监测。长期PM2.5浓度的四分位数增加（3 μg/m3）与FMD降低0.3%相关（差异的95%置信区间[CI]：-0.6至-0.03; p = 0.03），调整人口统计学特征，传统风险因素，超声检查员和1/BAD。女性、非吸烟者、年轻参与者和高血压患者似乎显示出PM2.5与FMD的更大关联。FMD与PM2.5的短期变化无显著相关性（检查前一天，PM2.5每日每增加12微克/立方米，变化率为-0.1%[95%CI：-0.2至0.04]）。根据肱动脉超声结果，长期PM2.5暴露与内皮功能下降显著相关。这些发现可能阐明了空气污染与心血管死亡率之间的重要联系。
This study evaluated the association of long- and short-term air pollutant exposures with flow-mediated dilation (FMD) and baseline arterial diameter (BAD) of the brachial artery using ultrasound in a large multicity cohort. Exposures to ambient air pollution, especially long-term exposure to particulate matter <2.5 μm in aerodynamic diameter (PM2.5), are linked with cardiovascular mortality. Short-term exposure to PM2.5 has been associated with decreased FMD and vasoconstriction, suggesting that adverse effects of PM2.5 may involve endothelial dysfunction. However, long-term effects of PM2.5 on endothelial dysfunction have not been investigated. FMD and BAD were measured by brachial artery ultrasound at the initial examination of the Multi-Ethnic Study of Atherosclerosis. Long-term PM2.5 concentrations were estimated for the year 2000 at each participant’s residence (n = 3,040) using a spatio-temporal model informed by cohort-specific monitoring. Short-term PM2.5 concentrations were based on daily central-site monitoring in each of the 6 cities. An interquartile increase in long-term PM2.5 concentration (3 μg/m3) was associated with a 0.3% decrease in FMD (95% confidence interval [CI] of difference: −0.6 to −0.03; p = 0.03), adjusting for demographic characteristics, traditional risk factors, sonographers, and 1/BAD. Women, nonsmokers, younger participants, and those with hypertension seemed to show a greater association of PM2.5 with FMD. FMD was not significantly associated with short-term variation in PM2.5 (−0.1% per 12 μg/m3 daily increase [95% CI: −0.2 to 0.04] on the day before examination). Long-term PM2.5 exposure was significantly associated with decreased endothelial function according to brachial ultrasound results. These findings may elucidate an important pathway linking air pollution and cardiovascular mortality.
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DOI：
10.1016/s0735-1097(99)00537-9
发表时间：
2000-01-01
影响因子：
24
作者：
Anderson, TJ;Elstein, E;Charbonneau, F
通讯作者：
Charbonneau, F
影响因子：
37.8
作者：
Benjamin, EJ;Larson, MG;Vita, JA
通讯作者：
Vita, JA
影响因子：
8.3
作者：
Briet, Marie;Collin, Cedric;Boutouyrie, Pierre
通讯作者：
Boutouyrie, Pierre
影响因子：
37.8
作者：
O'Neill, MS;Veves, A;Schwartz, J
通讯作者：
Schwartz, J
影响因子：
10.4
作者：
Li, Zhuowei;Carter, Jacqueline D;Dailey, Lisa A;Huang, Yuh-Chin T
通讯作者：
Huang, Yuh-Chin T