Astrocytes and the modulation of sleep.
Astrocytes and the modulation of sleep.
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星形胶质细胞和睡眠的调节。
DOI：
10.1016/j.conb.2017.02.008
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发表时间：
2017-06
影响因子：
5.7
通讯作者：
Haydon PG
中科院分区：
文献类型：
--
作者：
Haydon PG
星形胶质细胞被认为在睡眠中有多种作用。最初，它们被证明通过释放作用于腺苷A1受体（A1 R）的腺苷来调节睡眠稳态的过程，以促进睡眠驱动。最近的研究表明，星形胶质细胞在睡眠中也起着关键的、依赖于睡眠的“清洁大脑”作用。这项工作表明，严重依赖于星形胶质细胞水通道蛋白4的胶质淋巴通路能够从大脑中冲洗溶质，并且该通路中的缺陷可能导致阿尔茨海默病。最后，已知星形胶质细胞发挥重要的代谢作用，并通过星形胶质细胞-神经元穿梭按需向神经元提供能量。考虑到星形胶质细胞功能的时间进程比神经元慢几个数量级，这种非神经元细胞被完美地调节大脑中缓慢的状态依赖性变化。
Astrocytes are being identified as having multiple roles in sleep. Initially they were shown to modulate the process of sleep homeostasis through the release of adenosine which acts on adenosine A1 receptors (A1R) to promote sleep drive. More recent studies indicate that the astrocyte also plays pivotal, sleep-dependent roles in “cleaning the brain” during sleep. This work indicates that a glymphatic pathway that critically relies on astrocytic aquaporin 4, is able to flush solutes from the brain and that deficits in this pathway may contribute to Alzheimer’s disease. Finally, astrocytes are known to play important metabolic roles and provide energy on demand to neurons through an astrocyte-neuron shuttle. Given that the time course of astrocytic function is orders of magnitude slower than that of the neuron, this non-neuronal cell is perfectly tuned to modulating slow, state dependent changes in the brain.
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DOI：
10.1038/nrneurol.2015.119
发表时间：
2015-08
期刊：
Nature reviews. Neurology
影响因子：
--
作者：
Tarasoff-Conway JM;Carare RO;Osorio RS;Glodzik L;Butler T;Fieremans E;Axel L;Rusinek H;Nicholson C;Zlokovic BV;Frangione B;Blennow K;Ménard J;Zetterberg H;Wisniewski T;de Leon MJ
通讯作者：
de Leon MJ
DOI：
10.1126/science.1180962
发表时间：
2009-11-13
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Kang JE;Lim MM;Bateman RJ;Lee JJ;Smyth LP;Cirrito JR;Fujiki N;Nishino S;Holtzman DM
通讯作者：
Holtzman DM
影响因子：
56.9
作者：
Pascual, O;Casper, KB;Haydon, PG
通讯作者：
Haydon, PG
影响因子：
64.8
作者：
PARPURA, V;BASARSKY, TA;HAYDON, PG
通讯作者：
HAYDON, PG
影响因子：
64.8
作者：
通讯作者：
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