Recent Advances in Understanding the Role of Cartilage Lubrication in Osteoarthritis.
Recent Advances in Understanding the Role of Cartilage Lubrication in Osteoarthritis.
复制标题
了解软骨润滑在骨关节炎中的作用的最新进展
DOI：
10.3390/molecules26206122
复制
发表时间：
2021-10-11
期刊：
影响因子：
--
通讯作者：
Xie R
中科院分区：
文献类型：
--
作者：
Li Y;Yuan Z;Yang H;Zhong H;Peng W;Xie R
正常关节软骨的显著润滑特性在日常生活中起着重要作用，提供几乎无摩擦的关节运动。软骨表面的改变或滑液中生物大分子的降解增加了软骨的磨损和撕裂，因此决定了最常见的关节疾病骨关节炎（OA）的发作。关节软骨的不可逆和进行性退化是OA的标志。考虑到缺乏治疗OA的有效选择，软骨细胞的机械敏感性引起了人们的关注。作为软骨中唯一的嵌入细胞，软骨细胞的代谢对于维持软骨的稳态至关重要，这激发了人们了解软骨低摩擦背后的原因并开发基于生物润滑的策略来推迟甚至可能治愈OA的动机。本文首先对软骨润滑机制，特别是边界润滑机制进行了综述。然后讨论了软骨细胞的力学传递（特别是切应力）。以下总结了软骨启发的生物润滑剂的最新发展，以强调软骨润滑和OA之间的相关性。人们可能期望在OA的早期阶段恢复软骨润滑可以潜在地促进软骨再生并逆转其病理以治愈OA。
The remarkable lubrication properties of normal articular cartilage play an essential role in daily life, providing almost frictionless movements of joints. Alterations of cartilage surface or degradation of biomacromolecules within synovial fluid increase the wear and tear of the cartilage and hence determining the onset of the most common joint disease, osteoarthritis (OA). The irreversible and progressive degradation of articular cartilage is the hallmark of OA. Considering the absence of effective options to treat OA, the mechanosensitivity of chondrocytes has captured attention. As the only embedded cells in cartilage, the metabolism of chondrocytes is essential in maintaining homeostasis of cartilage, which triggers motivations to understand what is behind the low friction of cartilage and develop biolubrication-based strategies to postpone or even possibly heal OA. This review firstly focuses on the mechanism of cartilage lubrication, particularly on boundary lubrication. Then the mechanotransduction (especially shear stress) of chondrocytes is discussed. The following summarizes the recent development of cartilage-inspired biolubricants to highlight the correlation between cartilage lubrication and OA. One might expect that the restoration of cartilage lubrication at the early stage of OA could potentially promote the regeneration of cartilage and reverse its pathology to cure OA.
登录
查看更多内容
影响因子：
--
作者：
Antonacci, Jennifer M.;Schmidt, Tannin A.;Serventi, Lisa A.;Cai, Matthew Z.;Shu, Yuyu L.;Schumacher, Barbara L.;McIlwraith, C. Wayne;Sah, Robert L.
通讯作者：
Sah, Robert L.
影响因子：
3.3
作者：
Sophia Fox AJ;Bedi A;Rodeo SA
通讯作者：
Rodeo SA
影响因子：
--
作者：
Elsaid, Khaled A.;Jay, Gregory D.;Chichester, Clinton O.
通讯作者：
Chichester, Clinton O.
影响因子：
33.7
作者：
Bajpayee, Ambika G.;Grodzinsky, Alan J.
通讯作者：
Grodzinsky, Alan J.
影响因子：
56.9
作者：
Chen, Meng;Briscoe, Wuge H.;Klein, Jacob
通讯作者：
Klein, Jacob