Comprehensive risk profiles of family history and lifestyle and metabolic risk factors in relation to diabetes: A prospective cohort study.
Comprehensive risk profiles of family history and lifestyle and metabolic risk factors in relation to diabetes: A prospective cohort study.
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DOI：
10.1111/1753-0407.13289
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发表时间：
2022-06
影响因子：
4.5
通讯作者：
中科院分区：
文献类型：
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糖尿病家族史、不健康的生活方式和代谢紊乱分别与糖尿病的高风险相关，但这三种风险类别的不同组合如何与糖尿病事件相关仍不清楚。我们的目的是评估家族史、生活方式和代谢危险因素等综合风险特征与糖尿病风险的相关性。这项研究包括5290名基线时没有糖尿病的参与者，平均随访4.4年。五种不健康的生活方式和五种代谢紊乱各分配一个分数，导致综合生活方式和代谢风险分数从0到5不等。8个风险特征由三个风险类别的组合构建：糖尿病家族史（是，否），生活方式风险（高，低）和代谢风险（高，低）。与没有任何风险类别的概况相比，其他概况随着类别数量的增加而表现出越来越高的糖尿病风险：风险比（HR，95%置信区间[CI]）范围为1.34（1.01-1.79）至2.33（1.60-3.39）对于具有一个风险类别的概况，范围为2.42（1.45-4.04）到4.18（2.42-7.21）对于具有两个风险类别的概况，和4.59（2.85-7.39）对于具有三个风险类别的概况。风险类别的数量与糖尿病风险之间的关联在女性中更为突出（p交互作用= .025），在<55岁的成年人中略显着（p交互作用= .052）。这项研究描述了综合风险特征与糖尿病风险之间的关联，在女性中观察到更强的关联，在55岁以下的成年人中观察到略强的关联。与没有任何风险类别的概况相比，在具有一个风险类别的概况中，具有家族史的概况赋予最高的糖尿病风险（2.33倍）;在具有两个风险类别的概况中，具有家族史和高生活方式风险的概况赋予最高的糖尿病风险（4.18倍）;具有所有三个风险类别的概况赋予4.59倍的糖尿病风险增加。风险类别数量与糖尿病之间的关联在女性中更为突出，在55岁以下的成年人中略显着。综合全面的风险特征对于有效预测和预防糖尿病至关重要，特别是对于女性和年轻人。 亮点
Family history of diabetes, unhealthy lifestyles, and metabolic disorders are individually associated with higher risk of diabetes, but how different combinations of the three risk categories are associated with incident diabetes remains unclear. We aimed to estimate the associations of comprehensive risk profiles of family history and lifestyle and metabolic risk factors with diabetes risk. This study included 5290 participants without diabetes at baseline with a mean follow‐up of 4.4 years. Five unhealthy lifestyles and five metabolic disorders were each allocated a score, resulting in an aggregated lifestyle and metabolic risk score ranging from 0 to 5. Eight risk profiles were constructed from combinations of three risk categories: family history of diabetes (yes, no), lifestyle risk (high, low), and metabolic risk (high, low). Compared with the profile without any risk category, other profiles exhibited incrementally higher risks of diabetes with increasing numbers of categories: the hazard ratio (HR, 95% confidence interval [CI]) for diabetes ranged from 1.34 (1.01–1.79) to 2.33 (1.60–3.39) for profiles with one risk category, ranged from 2.42 (1.45–4.04) to 4.18 (2.42–7.21) for profiles with two risk categories, and was 4.59 (2.85–7.39) for the profile with three risk categories. The associations between the numbers of risk categories and diabetes risk were more prominent in women (p interaction = .025) and slightly more prominent in adults <55 years (p interaction = .052). This study delineated associations between comprehensive risk profiles with diabetes risk, with stronger associations observed in women and slightly stronger associations in adults younger than 55 years. Compared with the profile without any risk category, of profiles with one risk category, the profile with family history conferred the highest (2.33‐fold) diabetes risk; of profiles with two risk categories, the profile with family history and high lifestyle risk conferred the highest (4.18‐fold) diabetes risk; the profile with all three risk categories conferred 4.59‐fold increased diabetes risk. Associations between the risk category numbers and diabetes were more prominent in women and slightly more prominent in adults <55 years. Integrating comprehensive risk profiles is vital for effective prediction and prevention of diabetes, especially for women and younger adults. Highlights
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影响因子：
20.3
作者：
Kautzky-Willer A;Harreiter J;Pacini G
通讯作者：
Pacini G
影响因子：
16.2
作者：
American Diabetes Association
通讯作者：
American Diabetes Association
影响因子：
16.2
作者：
Cappuccio FP;D'Elia L;Strazzullo P;Miller MA
通讯作者：
Miller MA
影响因子：
39
作者：
Nyberg, Solja T.;Singh-Manoux, Archana;Kivimaki, Mika
通讯作者：
Kivimaki, Mika
影响因子：
4.5
作者：
Femlak M;Gluba-Brzózka A;Ciałkowska-Rysz A;Rysz J
通讯作者：
Rysz J