Fetal Organophosphate Pesticide Exposure and Child Adiposity Measures at 10 Years of Age in the General Dutch Population.
Fetal Organophosphate Pesticide Exposure and Child Adiposity Measures at 10 Years of Age in the General Dutch Population.
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DOI：
10.1289/ehp12267
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发表时间：
2023-08
影响因子：
10.4
通讯作者：
Jaddoe, Vincent W. V.
中科院分区：
文献类型：
--
作者：
Blaauwendraad, Sophia M.;Stevens, Danielle R.;van den Dries, Michiel A.;Gaillard, Romy;Pronk, Anjoeka;Spaan, Suzanne;Ferguson, Kelly K.;Jaddoe, Vincent W. V.
胎儿暴露于有机磷（OP）农药可能会导致胎儿代谢适应，使个体在以后的生活中代谢谱不良。我们研究了孕妇尿中OP农药代谢物浓度与10岁时后代体重指数（BMI）和脂肪测量值之间的关系。在2002年至2006年期间，我们纳入了来自R世代研究的642对母子，这是一项在荷兰鹿特丹进行的基于人群的前瞻性队列研究。我们测量了母体尿中OP农药代谢物的浓度，即二烷基磷酸盐，包括三个二甲基和三个二乙基磷酸盐在早期，中期和晚期妊娠。在10岁时，通过双能X线吸收测量法测量儿童总和局部体脂和瘦体重，通过磁共振成像测量腹部和器官脂肪。孕妇尿中平均或孕期特异性二烷基、二甲基或二乙基磷酸盐浓度较高与儿童期BMI和超重风险无关。此外，我们没有观察到任何关联的二烷基，二甲基，或二乙基磷酸盐浓度与总的和区域的身体脂肪，腹部内脏脂肪，肝脏脂肪，或心包脂肪的儿童年龄为10岁。我们没有观察到母亲在怀孕期间尿中二烷基浓度与10岁时儿童肥胖的相关性。这些联系是否在老年时发展，还有待进一步研究。https://doi.org/10.1289/EHP12267
Fetal exposure to organophosphate (OP) pesticides might lead to fetal metabolic adaptations, predisposing individuals to adverse metabolic profiles in later life. We examined the association of maternal urinary OP pesticide metabolite concentrations in pregnancy with offspring body mass index (BMI) and fat measures at 10 years of age. Between 2002 and 2006, we included 642 mother–child pairs from the Generation R Study, a population-based prospective cohort study in Rotterdam, the Netherlands. We measured maternal urinary concentrations of OP pesticide metabolites, namely, dialkyl phosphates, including three dimethyl and three diethyl phosphates in early-, mid- and late-pregnancy. At 10 years of age, child total and regional body fat and lean mass were measured through dual energy X-ray absorptiometry, and abdominal and organ fat through magnetic resonance imaging. Higher maternal urinary pregnancy-average or trimester-specific dialkyl, dimethyl, or diethyl phosphate concentrations were not associated with childhood BMI and the risk of overweight. In addition, we did not observe any association of dialkyl, dimethyl, or diethyl phosphate concentrations with total and regional body fat, abdominal visceral fat, liver fat, or pericardial fat at child age of 10 y. We observed no associations of maternal urinary dialkyl concentrations during pregnancy with childhood adiposity measures at 10 years of age. Whether these associations develop at older ages should be further studied. https://doi.org/10.1289/EHP12267
影响因子：
10.4
作者：
Barr, Dana B;Angerer, Jurgen
通讯作者：
Angerer, Jurgen