Berries vs. Disease: Revenge of the Phytochemicals.
Berries vs. Disease: Revenge of the Phytochemicals.
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DOI：
10.3390/ph17010084
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发表时间：
2024-01-09
期刊：
影响因子：
--
通讯作者：
Oghumu S
中科院分区：
文献类型：
--
作者：
Lamenza FF;Upadhaya P;Roth P;Shrestha S;Jagadeesha S;Horn N;Pracha H;Oghumu S
已知植物性饮食中的次生代谢物和植物化学物质具有抑制几种疾病发展的特性，包括各种呼吸消化道癌症。浆果目前引起了研究人员的高度兴趣，因为它们含有大量的植物化学物质。西方悬钩子，因其丰富多样的植物化学成分而备受人们的关注。在这篇综述中，我们介绍了最新的临床前和临床数据，涉及浆果及其植物化学物质在化学预防各种癌症和疾病中的作用。BRB具有多种健康益处，包括抗增殖特性、抗炎活性、激活促细胞死亡途径、调节免疫反应、微生物群调节、减少氧化应激等。然而，在临床前和临床环境中，很少有人研究BRB与其他癌症治疗方法联合应用对患者的影响。由于BRBs作为化学预防药物的潜力很大，有必要研究它们与其他治疗方法联合使用的潜力，以提高治疗效果。
Secondary metabolites and phytochemicals in plant-based diets are known to possess properties that inhibit the development of several diseases including a variety of cancers of the aerodigestive tract. Berries are currently of high interest to researchers due to their high dietary source of phytochemicals. Black raspberries (BRB), Rubus occidentalis, are of special interest due to their rich and diverse composition of phytochemicals. In this review, we present the most up-to-date preclinical and clinical data involving berries and their phytochemicals in the chemoprevention of a variety of cancers and diseases. BRBs possess a variety of health benefits including anti-proliferative properties, anti-inflammatory activity, activation of pro-cell-death pathways, modulation of the immune response, microbiome modulation, reduction in oxidative stress, and many more. However, little has been done in both preclinical and clinical settings on the effects of BRB administration in combination with other cancer therapies currently available for patients. With the high potential for BRBs as chemopreventive agents, there is a need to investigate their potential in combination with other treatments to improve therapeutic efficacy.
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DOI：
10.3390/antiox12091667
发表时间：
2023-08-24
期刊：
Antioxidants (Basel, Switzerland)
影响因子：
--
作者：
通讯作者：
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影响因子：
29.4
作者：
Cruz-Correa, M;Hylind, LM;Giardiello, FM
通讯作者：
Giardiello, FM
DOI：
10.3390/molecules26154669
发表时间：
2021-08-02
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Sarowska J;Wojnicz D;Jama-Kmiecik A;Frej-Mądrzak M;Choroszy-Król I
通讯作者：
Choroszy-Król I
影响因子：
5.9
作者：
Bayazid AB;Lim BO
通讯作者：
Lim BO
DOI：
10.1080/01635580903285148
发表时间：
2009
期刊：
Nutrition and cancer
影响因子：
--
作者：
Zikri NN;Riedl KM;Wang LS;Lechner J;Schwartz SJ;Stoner GD
通讯作者：
Stoner GD