The signaling pathway involved in the proliferation of corneal endothelial cells
The signaling pathway involved in the proliferation of corneal endothelial cells
复制标题
角膜内皮细胞增殖相关信号通路
DOI：
10.3109/10799893.2015.1026445
复制
发表时间：
2015-09
期刊：
影响因子：
--
通讯作者：
Xianqun Fan
中科院分区：
文献类型：
--
作者：
Weijie Zhang;Junzhao Chen;Yao Fu;Xianqun Fan
摘要角膜内皮通过其屏障和离子泵功能维持角膜的透明性。然而，随着年龄、各种疾病和创伤的增加，这一功能可能会受到损害，导致角膜代偿困难、角膜水肿、大泡性角膜病变，甚至丧失视力。到目前为止，已经提出了许多措施来解决这一问题，无论是在体内还是在体外都通过促进角膜内皮细胞的增殖来解决这一问题。然而，关于CECs增殖潜能和相关表型维持的确切分子机制还没有很好地阐明。因此，我们将对CECs增殖过程中涉及的信号转导途径进行综述，这是未来角膜内皮功能障碍新疗法的重要研究方向，也是相对较少涉及的研究方向。通过操作这些通路中的关键信号分子，我们期望激活或阻断这些信号通路，从而帮助设计CEC单层用于临床移植。
Abstract Corneal transparency is maintained by the corneal endothelium through its barrier and ionic pump function. However, this function could be compromised with age and variety of diseases and trauma, leading to cornea dycompensation, corneal edema, bullous keratopathy and even loss of visual acuity. So far, a lot of measures have been proposed to solve the problem through promoting the corneal endothelial cells (CECs) proliferation both in vivo and in vitro. However, the exact molecular mechanism regarding the proliferation potential as well as associated phenotype maintenance of CECs has not been well clarified. Accordingly, we will review the studies outlined the signal transduction pathways that were involved in the process of CECs proliferation, which is an important and relatively seldom touched research direction for future new therapies of corneal endothelium dysfunction. By operating the crucial signaling molecular in these pathways, we anticipate to activate or block the signaling pathways and thus help engineering CEC monolayer for clinical transplantation.
登录
查看更多内容
影响因子：
4.8
作者：
Sumide, Taizo;Nishida, Kohji;Tano, Yasuo
通讯作者：
Tano, Yasuo
影响因子：
4.4
作者：
T. Y. Kim;W. Kim;R. Smith;E. D. Kay
通讯作者：
T. Y. Kim;W. Kim;R. Smith;E. D. Kay
影响因子：
4.4
作者：
J. Albon;Aihua Ma;J. Cai;M. Boulton
通讯作者：
J. Albon;Aihua Ma;J. Cai;M. Boulton
影响因子：
2.2
作者：
K. Konomi;N. Joyce
通讯作者：
K. Konomi;N. Joyce
影响因子：
5.6
作者：
J. Plouët;D. Gospodarowicz
通讯作者：
J. Plouët;D. Gospodarowicz