Morphological changes of cerebral vessels and expression patterns of MMP-2 and MMP-9 on cerebrovascular wall of alcoholic rats.
Morphological changes of cerebral vessels and expression patterns of MMP-2 and MMP-9 on cerebrovascular wall of alcoholic rats.
复制标题
酒精大鼠脑血管形态变化及脑血管壁MMP-2、MMP-9表达模式
DOI：
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发表时间：
2014-04
期刊：
影响因子：
--
通讯作者：
Li, Yingmin
中科院分区：
文献类型：
--
作者：
He, Wenjing;Ma, Rufei;Cong, Bin;Li, Yingmin
酒精滥用可增加脑血管意外的发生率，并与脑血管结构改变有关。本研究应用光镜和透射电镜观察了饮酒大鼠脑血管重构。短期酒精给药可引起脑组织小血管周围的血管周围空间明显扩大，而长期酒精给药可引起基底动脉（BA）的病理变化，包括内皮剥脱、内弹性膜（IEL）断裂和图尼卡中膜和外膜增厚。此外，通过免疫组化方法探讨血管内皮细胞和血管平滑肌细胞合成MMP-2和MMP-9与脑血管重构的关系。两种蛋白在脑血管中的表达呈动态变化，在治疗后1-2周达到高峰，随治疗持续而下降。这些结果表明，MMP-2和MMP-9可能在酒精滥用后血脑屏障破坏中发挥重要作用。而饮酒后脑动脉的慢性变化与MMP-2、MMP-9在脑组织中的表达时间不一致。
Alcohol abuse increases the incidence of cerebral accidents, which correlates with cerebrovascular structural changes. The present study was designed to observe the cerebrovascular remodeling of drinking rats with light microscopy and transmission electron microscopy (TEM). Short-term alcohol administration induced apparent amplification of perivascular spaces around small vessels in brain tissue, while long-term administration caused pathological changes of basilar arteries (BAs), including endothelial exfoliation, inner elastic lamina (IEL) fragmentation and thickening of tunica media and adventitia. In addition, the relationship between cerebrovascular remodeling and MMP-2 and MMP-9 synthesized by endothelial cells and vascular smooth muscle cells was explored by immunohistochemistry. The two protein expression in cerebral vessels changed dynamically, peaking at 1-2 weeks after treatment, and decreasing as treatment continued. These results suggest that MMP-2 and MMP-9 may play a significant role in blood-brain barrier disruption after alcohol abuse. But the chronic changes of cerebral arteries resulted from drinking are not coincident with time course of MMP-2 and MMP-9 expression in situ.
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影响因子：
3.3
作者：
S. Q. Liu
通讯作者：
S. Q. Liu
DOI：
10.1097/01.alc.0000130811.92457.0d
发表时间：
2004-07-01
影响因子：
3.2
作者：
Kuhlmann, CRW;Li, F;Wiecha, J
通讯作者：
Wiecha, J
DOI：
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发表时间：
1996-11
期刊：
The American journal of pathology
影响因子：
--
作者：
S. Nikkari;M. Höyhtyä;J. Isola;T. Nikkari
通讯作者：
S. Nikkari;M. Höyhtyä;J. Isola;T. Nikkari
酒精中毒与外伤性蛛网膜下腔出血：血管形态学和生物力学的实验研究
DOI：
10.1097/ta.0b013e3181cda3b9
发表时间：
2011-01-01
影响因子：
--
作者：
Wang, Haipeng;Yu, Xiaojun;Xu, Xiaohu
通讯作者：
Xu, Xiaohu
影响因子：
2.9
作者：
J. Wright;Alex J Masino;Jennifer R Reichert;Gary D Turner;Starla E. Meighan;P. Meighan;J. Harding
通讯作者：
J. Wright;Alex J Masino;Jennifer R Reichert;Gary D Turner;Starla E. Meighan;P. Meighan;J. Harding